On the association between appendicitis and ABO blood groups

Increased Frequency of Rh (E) in Acute Appendicitis

“…We found this disease to be associated with the Rh(E) antigen more frequently than what would be expected by chance. In the light of the results of our previous genetic marker studies [2,3], another genetic fac tor in acute appendicitis reported in this paper supports the hypothesis of a multifactorial etiology of this common disorder [ …”

“…The results of our popula tion genetic study indicated a genetic de termination of the familiality of acute ap pendicitis and a possible polygenic mode of inheritance [1], We have further sup ported this hypothesis by demonstrating the association between appendicits and ABO blood groups [2], and a probable link age with the HLA system [3]. In this study the only marker tested on children with acute appendicitis was Rh.…”

Heredity and Familial Tendency of Acute Appendicitis

“…This means that almost half of the variability in risk of acute appendicitis is due to random environmental factors. Basta et al have further supported the hypothesis of familiality of acute appendicitis and apossible polygenic mode of inheritance by demonstratingt he association between appendicitis and AB0 blood group (26), and aprobable linkage with the HlAs ystem. They have found that blood group-A have am uch higher risk of having appendicitis than those of group-o.…”

Familial history aggregation on acute appendicitis

“…By studying the families of 80 patients, he found no evidence of a major gene involved, but a multifactorial or polygenic model with a 56% total heritability and a relative risk of 10.0 (95% CI 4.7 to 21.4), that varied in relation to kinship grade (21% for first-grade family, 12% for second-grade family and 7% for third-grade family) 32. Basta  et al showed that an association between phenotype CcD-Ee Rh33 and the blood group A, when compared with the O group,34 being found in more proportion in patients with appendicitis when compared with the control group.…”