We prove the existence of solutions to the asymptotic Plateau problem for hypersurfaces of prescribed mean curvature in Cartan-Hadamard manifolds N . More precisely, given a suitable subset L of the asymptotic boundary of N and a suitable function H on N , we are able to construct a set of locally finite perimeter whose boundary has generalized mean curvature H provided that N satisfies the so-called strict convexity condition and that its sectional curvatures are bounded from above by a negative constant. We also obtain a multiplicity result in low dimensions.2000 Mathematics Subject Classification. 53A10, 53C42, 49Q05, 49Q20.