2006
DOI: 10.1007/s00441-006-0218-0
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On the atrophy of the internal carotid artery in capybara

Abstract: Capybara might be a useful model for studying changes in cerebral circulation as the natural atrophy of the internal carotid artery (ICA) occurs in this animal at maturation. In this study, confocal and electron microscopy combined with immunohistochemical techniques were applied in order to reveal the changes in morphology and innervation to the proximal part of ICA in young (6-month-old) and mature (12-month-old) capybaras. Some features of the basilar artery (BA) were also revealed. The ICA of young animals… Show more

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Cited by 14 publications
(24 citation statements)
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“…This study also revealed that the ET-1-positive perivascular nerves, including both axon profiles and accompanying Schwann cells, underwent changes at animal maturation coinciding with ICA regression. Our findings, therefore, supplement our previous data on the fine structure of the BA in capybaras and to the artery changes during animal maturation and ICA regression [Islam et al, 2004;Loesch et al, 2005;Steele et al, 2006]. It should be mentioned, however, that it has previously been demonstrated that in a large proportion of capybaras at maturation (which is at about 1 year of age), the ICA is no longer functioning efficiently due to the collapsed lumen, decreased lumen size and transformation to a ligamentous cord.…”
Section: Discussionsupporting
confidence: 53%
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“…This study also revealed that the ET-1-positive perivascular nerves, including both axon profiles and accompanying Schwann cells, underwent changes at animal maturation coinciding with ICA regression. Our findings, therefore, supplement our previous data on the fine structure of the BA in capybaras and to the artery changes during animal maturation and ICA regression [Islam et al, 2004;Loesch et al, 2005;Steele et al, 2006]. It should be mentioned, however, that it has previously been demonstrated that in a large proportion of capybaras at maturation (which is at about 1 year of age), the ICA is no longer functioning efficiently due to the collapsed lumen, decreased lumen size and transformation to a ligamentous cord.…”
Section: Discussionsupporting
confidence: 53%
“…Brains were dissected out, and the BA isolated and placed in the same fixative for further fixation and storage (at 4-8 ° C) for about 1 week. All 9 adult capybaras (12-18 months old) displayed ICA regression, which appeared as a more or less advanced ligamentous cord [Reckziegel et al, 2001;Steele et al, 2006] on postmortem examination.…”
Section: Animalsmentioning
confidence: 99%
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