On The Beta-Glucuronidase Binding Protein (BGBP) Of Microorganisms

Matsuo, Eiichi; Komatsu, Akio; Maekawa, Suguru; Furuno, Yukihiro; Matsushita, Akiko; Sumiishi, Ayumi; N, Sasaki; Skinsnes, Olaf K.

doi:10.5025/hansen1977.63.35

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“…The main component of culture medium, HA was replaced by its split products, namely glucuronic acid (GA) and N-acetylglucosamine (NAG) (Fig. 2) (28). The reason was that HI-75 can not obtain GA and NAG by enzymatically splitting HA in culture tube since the bacillus can not produce the enzyme which is able to work so (28).…”

Section: On the Hi-75 After The Denials To Be Cultured M Leprae And I...mentioning

confidence: 99%

“…2) (28). The reason was that HI-75 can not obtain GA and NAG by enzymatically splitting HA in culture tube since the bacillus can not produce the enzyme which is able to work so (28). As the basis of that reason, histochemical and immunohistochemical studies showed that HI-75 in leproma produce a kind of lectin, which is BGBP (28) and accumulate β-glucuronidase (B-Gase) from host human (Fig.…”

Section: On the Hi-75 After The Denials To Be Cultured M Leprae And I...mentioning

confidence: 99%

“…The antibody preparation against human B-Gase and its application to the cases of nephropathy were reported elsewhere (30,31). The change from the original to Ogawa's medium (3%) to culture HI-75 was due to the commercial availability of Ogawa's medium which makes the rest of the modification much simpler (28).…”

Section: On the Hi-75 After The Denials To Be Cultured M Leprae And I...mentioning

confidence: 99%

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Leprosy as a Challenge to Science on the Ability to Decode Its Enigma. A Hypothesis on How to Respond

Matsuo

2005

Jpn J Infect Dis

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In world leprosy nowadays, a favorable epidemiologic trend has been provided due to the best effort of the worldwide campaign with chemotherapy providing a bright but one-sided look at the future. However, the numbers of new patients are still higher than those under chemotherapy, leaving a concern over the remaining non-human source of infection. To overcome that plausibility, overall understanding of the etiology of the disease should be improved. The author discussed this by the analyses of historical and scientific legitimacy of the current idea about the etiology of leprosy that have unreasonably rejected the possibility of dual infections in relation to that of Mycobacterium leprae. The analyses also consider the author's ongoing effort to know the feasibility of artificial culture of M. leprae by improving of the former methods reported by Skinsnes et al. and has been rejected as it contained Mycobacterium scrofulaceum, without attention to the coexistent M. leprae at that time. The bacillus thus maintained with the modification of the medium still shows PGL-1 immunoreactivity and the pathogenicity to cause neuropathy in mice. These strongly suggest the coexistence of the above two bacilli throughout past years. The genomic study is in progress to prove that hypothesis, the genomes should be alike in nature if proven.

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Section: On the Hi-75 After The Denials To Be Cultured M Leprae And I...mentioning

confidence: 99%

Section: On the Hi-75 After The Denials To Be Cultured M Leprae And I...mentioning

confidence: 99%

Section: On the Hi-75 After The Denials To Be Cultured M Leprae And I...mentioning

confidence: 99%

See 1 more Smart Citation

Leprosy as a Challenge to Science on the Ability to Decode Its Enigma. A Hypothesis on How to Respond

Matsuo

2005

Jpn J Infect Dis

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On The Beta-Glucuronidase Binding Protein (BGBP) Of Microorganisms

Abstract: Our previous studies suggested that M. leprae (ML) grow in peripheral nerves and lepra cells because ML metabolize hyaluronic acid (HA), the host with the similar ways to that of ML.

Cited by 1 publication

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Leprosy as a Challenge to Science on the Ability to Decode Its Enigma. A Hypothesis on How to Respond

Leprosy as a Challenge to Science on the Ability to Decode Its Enigma. A Hypothesis on How to Respond

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