On the Bone Tumours: Overview, Classification, Incidence, Histopathological Issues, Behavior and Review Using Literature Data

Sisu, Alina Maria; Stana, Loredana Gabriela; Petrescu, Cristina; Tatu, Romulus Fabian; Folescu, Roxana; Motoc, Andrei Gheorghe Marius

doi:10.5772/52969

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…There are several types of bone tumors, of which osteosarcoma is the most common, representing 31.5% of cases, followed by angiosarcoma and chondroma. 86 Recent research aimed at bone repair for bone cancer has as its objective the development of bioimplants capable of not only carrying out antitumor treatment but also promoting bone regeneration. Hydrogels are a promising form of implants with which to perform both functions.…”

Section: Applications In Bone Cancermentioning

confidence: 99%

The Era of Biomaterials: Smart Implants?

Silva-López

Alcántara-Quintana

2023

ACS Appl. Bio Mater.

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Conditions, accidents, and aging processes have brought with them the need to develop implants with higher technology that allow not only the replacement of missing tissue but also the formation of tissue and the recovery of its function. The development of implants is due to advances in different areas such as molecular-biochemistry (which allows the understanding of the molecular/cellular processes during tissue repair), materials engineering, tissue regeneration (which has contributed advances in the knowledge of the properties of the materials used for their manufacture), and the so-called intelligent biomaterials (which promote tissue regeneration through inductive effects of cell signaling in response to stimuli from the microenvironment to generate adhesion, migration, and cell differentiation processes). The implants currently used are combinations of biopolymers with properties that allow the formation of scaffolds with the capacity to mimic the characteristics of the tissue to be repaired. This review describes the advances of intelligent biomaterials in implants applied in different dental and orthopedic problems; by means of these advances, it is expected to overcome limitations such as additional surgeries, rejections and infections in implants, implant duration, pain mitigation, and mainly, tissue regeneration.

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Section: Applications In Bone Cancermentioning

confidence: 99%

The Era of Biomaterials: Smart Implants?

Silva-López

Alcántara-Quintana

2023

ACS Appl. Bio Mater.

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Nanocarrier-based drug delivery systems for bone cancer therapy: a review

2021

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Bone cancer is a malignant tumor that originates in the bone and destroys the healthy bone tissues. Of the various types of bone tumors, osteosarcoma is the most commonly diagnosed primary bone malignancy. The standard treatment for primary malignant bone tumors comprises surgery, chemotherapy and radiotherapy. Owing to the lack of proven treatments, different forms of alternative therapeutic approaches have been examined in recent decades. Among the new therapeutic methodologies, nanotechnology-based anticancer therapy has paved the way for new targeted strategies for bone cancer treatment and bone regeneration. They include approaches such as the co-delivery of multiple drug cargoes, the enhancement of their biodistribution and transport properties, normalizing accumulation and the optimization of drug release profiles to overcome shortcomings of the existing therapy. This review examines the standard treatments for osteosarcoma, their lacunae, and the evolving therapeutic strategies based on nanocarrier-mediated combinational drug delivery systems, and future perspectives for osteosarcoma therapy.

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On the Bone Tumours: Overview, Classification, Incidence, Histopathological Issues, Behavior and Review Using Literature Data

Cited by 2 publications

References 13 publications

The Era of Biomaterials: Smart Implants?

The Era of Biomaterials: Smart Implants?

Nanocarrier-based drug delivery systems for bone cancer therapy: a review

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