In filtration 1 of the Adams spectral sequence, using secondary cohomology operations, Adams (Ann. Math. (2) 72:20–104 1960) computed the differentials on the classes $h_{j}$
h
j
, resolving the Hopf invariant one problem. In Adams filtration 2, using equivariant and chromatic homotopy theory, Hill–Hopkins–Ravenel (Ann. Math. (2) 184(1):1–262 2016) proved that the classes $h_{j}^{2}$
h
j
2
support non-trivial differentials for $j \geq 7$
j
≥
7
, resolving the celebrated Kervaire invariant one problem. The precise differentials on the classes $h_{j}^{2}$
h
j
2
for $j \geq 7$
j
≥
7
and the fate of $h_{6}^{2}$
h
6
2
remains unknown. In this paper, in Adams filtration 3, we prove an infinite family of non-trivial $d_{4}$
d
4
-differentials on the classes $h_{j}^{3}$
h
j
3
for $j \geq 6$
j
≥
6
, confirming a conjecture of Mahowald. Our proof uses two different deformations of stable homotopy theory—ℂ-motivic stable homotopy theory and $\mathbb{F}_{2}$
F
2
-synthetic homotopy theory—both in an essential way. Along the way, we also show that $h_{j}^{2}$
h
j
2
survives to the Adams $E_{5}$
E
5
-page and that $h_{6}^{2}$
h
6
2
survives to the Adams $E_{9}$
E
9
-page.