The choice of an appropriate flow field distributor is crucial to circumvent mass and charge transfer resistance-related issues in proton exchange membrane fuel cells (PEMFCs). In this work, incorporating all the anisotropic nature of the gas diffusion layers (GDLs), a three-dimensional, multiphase CFD model is built to perform a comparative study of several types of cathode flow field designs. Three conventional (i.e. parallel, serpentine and interdigitated) and two recently-introduced (i.e. parallel with blocks and the metal foam) flow field designs were considered for the cathode side. The results showed that the best fuel cell performance is obtained with the metal foam flow field as it induces the lowest water saturation, the lowest values and more uniform distribution of current density and temperature as well as relatively medium pressure drop. Compared with the parallel flow field case, the peak power density increases by about 50% when using the metal foam flow field and by about 10% when using the other three investigated flow fields (i.e. serpentine, interdigitated and parallel with blocks). The parametric analysis reveals that the metal foam outperforms other designs at intermediate and high humidity conditions whereas the interdigitated flow field design outperforms other designs at low humidity conditions.