1967
DOI: 10.1017/s1120962300013263
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On the Concepts of Chronon and Chronaxy and their Implications in Neoplasia

Abstract: SummaryThe concepts of Chronon and Chronaxy of Gedda are discussed in the light of recent biochemical-genetic knowledge. It is proposed that the term «positive chronaxy» and «negative chronaxy» be employed to designate the period during which a gene is in active and inactive state, respectively. Other terms proposed are «recurrent positive chronaxy», «recurrent negative chronaxy» and « uncoordinated chronaxy». It is pointed out that the different chronaxy states of genes may be subject to modification by certa… Show more

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Cited by 4 publications
(3 citation statements)
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“…Such a possibility has been considered in the section on senescence (cf III.4). Bartalos (1967) referred directly to our thesis when he underlined the importance of the concept of chronon in neoplastic disease.…”
Section: Iii6 Diseasementioning
confidence: 93%
“…Such a possibility has been considered in the section on senescence (cf III.4). Bartalos (1967) referred directly to our thesis when he underlined the importance of the concept of chronon in neoplastic disease.…”
Section: Iii6 Diseasementioning
confidence: 93%
“…The temporal succession of gene activity states was called chronaxy by Gedda (1965). Later Bartalos (1967) proposed that the metabolically active phase of a gene be called positive chronaxy and the inactive one negative chronaxy. Other proposed terms included recurrent positive chronaxy and recurrent negative chronaxy referring respectively to the reactivation of a previously active gene which was subsequently inactivated and to the reinactivation of a previously inactive gene that subsequently became activated.…”
Section: Gene Action In T I M Ementioning
confidence: 99%
“…Interesting considerations have also been suggested by Bartalos (1967) about the relationships of the concept of chronon with the modern views of molecular genetics, and about the implications of chronon in neoplasia.…”
Section: Acta Geneticae Medicae Et Gemellologiaementioning
confidence: 99%