In this paper, we study the pullback attractor for a general reaction-diffusion system for which the uniqueness of solutions is not assumed. We first establish some general results for a multi-valued dynamical system to have a bi-spatial pullback attractor, and then we find that the attractor can be backwards compact and composed of all the backwards bounded complete trajectories. As an application, a general reaction-diffusion system is proved to have an invariant (H, V )-pullback attractor A = {A(τ )} τ ∈R . This attractor is composed of all the backwards compact complete trajectories of the system, pullback attracts bounded subsets of H in the topology of V , and moreoverA non-autonomous Fitz-Hugh-Nagumo equation is studied as a specific example of the reactiondiffusion system.