On the Constituents of the Rhizomes of Atractylodes lancea DC var. chinensis KITAMURA ("Jin-changzhu") and Atractylodes ovata DC ("Chinese baizhu") The Gas Chromatographic Analysis of the Crude Drug "Zhu"

Yosioka, Itiro; Nishino, Takao; Tani, Tohru; Kitagawa, Izumi

doi:10.1248/yakushi1947.96.10_1229

Cited by 17 publications

(12 citation statements)

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“…NMR spectra were recorded at 300 MHz ( 1 H) and 75 MHz ( 13 C) on a Varian VXR-300 spectrometer (1, 2, 6) or at 500 MHz ( 1 H) and 125 MHz ( 13 C) on a Bruker DRX 500 (3)(4)(5) in Cox-1 Assay. This assay was performed after the preparation of microsomal COX-1 from sheep seminal vesicles on a microtiter scale, 29 containing an incubation mixture of the microsomal fraction, 1 mM reduced glutathione, 1 mM L-adrenaline-D-hydrogen tartrate, and 0.05 mM Na 2 EDTA in 180 µL 0.1 M Tris buffer (pH 8.0).…”

Section: Methodsmentioning

confidence: 99%

“…General Experimental Procedures. NMR spectra were recorded at 300 MHz ( 1 H) and 75 MHz ( 13 C) on a Varian VXR-300 spectrometer (1, 2, 6) or at 500 MHz ( 1 H) and 125 MHz ( 13 C) on a Bruker DRX 500 (3)(4)(5) in CDCl 3 . Chemical shifts are expressed in δ values from TMS as internal standard, and coupling constants are given in Hertz.…”

Section: Methodsmentioning

confidence: 99%

“…[2][3][4][5][6] For Baizhu, sesquiterpenes (with the furosesquiterpene atractylon as the main compound) and acetylenic compounds have been described. 4,5,7 The antiinflammatory activity of this genus has been investigated previously when Yamahara et al found no significant analgesic activity in A. lancea, A. macrocephala, or A. japonica. 8 Endo et al fractionated a preparation from A. japonica rhizomes to afford the sesquiterpenes (+)-eudesma-4(14),7(11)-dien-8-one and atractylenolide I as active compounds in different antiinflammatory assays.…”

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confidence: 99%

“…rhizomes) has been recommended as a digestive, diuretic, and anhidrotic medication − For Baizhu, sesquiterpenes (with the furosesquiterpene atractylon as the main compound) and acetylenic compounds have been described. ,, The antiinflammatory activity of this genus has been investigated previously when Yamahara et al found no significant analgesic activity in A. lancea , A. macrocephala , or A. japonica . Endo et al.…”

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confidence: 99%

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5-Lipoxygenase and Cyclooxygenase-1 Inhibitory Active Compounds from Atractylodes lancea

et al. 1998

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Lipophilic extracts of Atractylodes lancea rhizomes exhibited potent inhibitory activities in 5-lipoxygenase [IC50 (5-LOX) = 2.9 micrograms/mL (n-hexane extract)] and cyclooxygenase-1 [IC50 (COX-1) = 30.5 micrograms/mL (n-hexane extract)] enzymatic assays. Bioactivity-guided fractionation of the n-hexane extract led to the isolation of a new compound atractylochromene (1), a potent inhibitor in both test systems [IC50 (5-LOX) = 0.6 microM, IC50 (COX-1) = 3.3 microM]. Also obtained was 2-[(2E)-3,7-dimethyl-2,6-octadienyl]-6-methyl-2,5-cyclohexadiene-1 ,4-dione (2), which showed a selective inhibitory activity against 5-LOX [IC50 (5-LOX) 0.2 microM, IC50 (COX-1) 64.3 microM]. The sesquiterpene atractylon (3) and the coumarin osthol (4) turned out to be moderate but selective 5-lipoxygenase inhibitors. Atractylenolides I (5), II (6), and III (7) showed no significant inhibitory effects for either enzyme. Structures were established by spectral data interpretation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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5-Lipoxygenase and Cyclooxygenase-1 Inhibitory Active Compounds from Atractylodes lancea

et al. 1998

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“…In addition, among the five species of Atractylodes, some interspecific hybridization has been reported. [17][18][19] It is necessary to observe a nuclear genetic marker to identify the hybrid. Chloroplast DNA is not suitable because chloroplast DNA is gener-ally inherited maternally or paternally.…”

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Identification of Medicinal Atractylodes Based on ITS Sequences of nrDNA

Shiba

Kondo

Miki

et al. 2006

Biological & Pharmaceutical Bulletin

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Dried rhizomes of five species of Atractylodes (A. japonica, A. macrocephala, A. lancea, A. chinensis, and A. koreana), Compositae, have been used as crude drugs mainly for the treatment of stomach disorders and for their diuretic properties in Chinese and Japanese traditional medicines. The identification of the botanical origins of these crude drugs is generally difficult from their morphological and chemical features only. In this study, for identification with more reliable, nuclear ribosomal DNA (nrDNA), internal transcribed spacer (ITS) regions of five species of medicinal Atractylodes were sequenced. As a result, specific ITS genotypes were recognized by each species. The four species (A. japonica, A. macrocephala, A. lancea, and A. chinensis) prescribed in Chinese and Japanese Pharmacopoeias as botanical origins of crude Atractylodes drugs could be distinguished by their ITS sequences because they had difference genotypes on the ITS sequences. However, the genotype of A. koreana was the same as that of A. chinensis. Additionally, hybrids between A. lancea and A. chinensis were also recognized as nucleotide additives on their ITS sequences. In this study, several morphological characteristics were researched by their genotype, too. As this result, the hybrids recognized from the genetic analysis had intermediate morphological characteristics between A. lancea and A. chinensis. It was also recognized that A. lancea and A. chinensis except for their hybrids were significant differences. It is therefore suggested that ITS sequences of nrDNA would be useful for the identification of the crude drugs derived from Atractylodes species and their interspecific hybridizations.

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Sesquiterpenoids Isolated from the Rhizomes of Genus Atractylodes

Kim

2022

Chemistry & Biodiversity

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Atractylodes plants have been used in traditional herbal medicine to treat gastrointestinal diseases and contain various chemical compounds. Sesquiterpenoids are the most important therapeutic compounds in Atractylodes rhizomes. Based on studies reported from 2000 to 2022, we classified sesquiterpenoids by their chemical skeletons and original resources. Moreover, we discussed their biosynthesis and physicochemical and pharmacological features. We reported sesquiterpenoids with skeletal moieties, such as monocyclic sesquiterpenes (bisabolene-and elemene-type), bicyclic sesquiterpenes (eudesmane-, isopterocarpolone-, hydroxycarissone-, eremophilane-, bisesquiterpenoid-, guaiane-and spirovetivane-type and eudesmane lactones) and tricyclic sesquiterpenes (cyperene-and patchoulene-type), with their biosynthetic pathways, chemical modifications and in vivo metabolites. The pharmacological activities of sesquiterpenoids as anti-inflammatory, anti-tumor, anti-diabetic and anti-microbial and for treating gastrointestinal disorders have been reported for this genus.

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On the Constituents of the Rhizomes of Atractylodes lancea DC var. chinensis KITAMURA ("Jin-changzhu") and Atractylodes ovata DC ("Chinese baizhu") The Gas Chromatographic Analysis of the Crude Drug "Zhu"

Cited by 17 publications

References 1 publication

5-Lipoxygenase and Cyclooxygenase-1 Inhibitory Active Compounds from Atractylodes lancea

5-Lipoxygenase and Cyclooxygenase-1 Inhibitory Active Compounds from Atractylodes lancea

Identification of Medicinal Atractylodes Based on ITS Sequences of nrDNA

Sesquiterpenoids Isolated from the Rhizomes of Genus Atractylodes

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