On the Crystallization of Hydroxyapatite under Hydrothermal Conditions: Role of Sebacic Acid as an Additive

In, Yongjae; Amornkitbamrung, Urasawadee; Hong, Min Ho

doi:10.1021/acsomega.0c03297

Cited by 47 publications

(34 citation statements)

References 48 publications

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“…However, the morphology of HA particles changed from spherical to flower-like and rod-like. Furthermore, irregular HA particles were deposited on the scaffolds when the pH value of the reaction solution was at 4 or 10, suggesting that the weakly acidic or alkaline environment of the original reaction solution facilitates to form regular HA particles, which was similar to other reported study [32]. On the other hand, the M 2 S-HA scaffolds were ultrasonically treated in deionized water bath for 30 s and rinsed with ethanol, and SEM observation confirmed that the deposited HA particles have not been dropped off from the scaffolds, suggesting that HA particles could stably bond to the surface of the scaffolds.…”

Section: Resultssupporting

confidence: 88%

Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair

et al. 2021

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Bone engineering scaffolds with antibacterial activity satisfy the repair of bacterial infected bone defects, which is an expected issue in clinical. In this work, 3D-printed polymer-derived forsterite scaffolds were proposed to be deposited with hydroxyapatite (HA) coating via a hydrothermal treatment, achieving the functions of photothermal-induced antibacterial ability and bioactivity. The results showed that polymer-derived forsterite scaffolds possessed the photothermal antibacterial ability to inhibit Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in vitro, owing to the photothermal effect of free carbon embedded in the scaffolds. The morphology of HA coating on forsterite scaffolds could be controlled through changing the hydrothermal temperature and the pH value of the reaction solution during hydrothermal treatment. Furthermore, HA coating did not influence the mechanical strength and photothermal effect of the scaffolds, but facilitated the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs) on scaffolds. Hence, the HA-deposited forsterite scaffolds would be greatly promising for repairing bacterial infected bone defects.

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Section: Resultssupporting

confidence: 88%

Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair

et al. 2021

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“…The revealed characteristic planes of NX-HAPs (410), (510), (400) and MB-NX-HAPs (002), (004), (510) represented the planes of hydroxyapatite as reported earlier (Figure S3B,C). The high-resolution TEM (HRTEM) suggested lattice spacings of 0.30 and 0.27 nm for NX-HAPs (Figure S3D) and MB-NX-HAPs (Figure S3E), respectively, corresponding to (210) and (300) planes of hydroxyapatite nanomaterial . Additionally, the energy-dispersive X-ray (EDX) spectroscopy investigation displayed the elemental composition of the as-synthesized NX-HAPs and MB-NX-HAPs (Figure S4A,B).…”

Section: Resultsmentioning

confidence: 98%

“…The high-resolution TEM (HRTEM) suggested lattice spacings of 0.30 and 0.27 nm for NX-HAPs (Figure S3D) and MB-NX-HAPs (Figure S3E), respectively, corresponding to (210) and (300) planes of hydroxyapatite nanomaterial. 37 Additionally, the energy-dispersive X-ray (EDX) spectroscopy investigation displayed the elemental composition of the as-synthesized NX-HAPs and MB-NX-HAPs (Figure S4A,B). Moreover, characterization using FESEM conveyed the size of NX-HAPs to be 67.5 ± 6.4 nm and that of MB-NX-HAPs to be 60.5 ± 3.5 nm, in support of the TEM data obtained (Figure S5A,B).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

Simon

Chattopadhyay

Ghosh

2022

ACS Appl. Bio Mater.

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Imminent prospects of clinical importance have been accomplished through divergent treatment modalities implemented using nanoscale platforms. In the present study, hydroxyapatite nanoparticles doped with copper nanoclusters (HAPs) were explored for codelivery of a hydrophobic drug, namely, norfloxacin (NX), and a hydrophilic photosensitizer, such as methylene blue (MB). NX and MB were successfully homed into HAPs (MB-NX-HAPs), which further exhibited a pH-dependent release of both. With the objective of attaining an enhanced effect, MB-NX-HAPs were evaluated for combination therapy, involving chemotherapy and photodynamic therapy (PDT) with irradiation at 640 nm. The combinatorial therapy approach was initially applied for antibacterial therapy, which suggested a considerable reduction in bacterial growth of Gram-negative strain Pseudomonas aeruginosa MTCC 2488. Thereafter, the antiproliferative study performed in cancer cell lines (HeLa and MCF-7) revealed the efficiency of MB-NX-HAPs in bestowing a combinatorial effect through chemotherapy and PDT (irradiation at 640 nm). The combined effect exerted through MB-NX-HAPs subsequently induced reactive oxygen species (ROS) generation, cell cycle alteration, and apoptosis activation in cancer cells. The biocompatible nature of MB-NX-HAPs was appreciably shown through their minimal effect on the normal cell line (HEK-293). Additionally, HAPs through luminescence of copper nanoclusters were suggested to aid in bioimaging of cancer cell lines.

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“…The Fourier transform infrared (FT-IR) spectra of the synthesized HAP·CeO 2 (HC), HAP·CeO 2 ·La(OH) 3 (2:1) (HCL 1), and HAP·CeO 2 ·La(OH) 3 (3:2) (HCL 2), given in Figure , show broad peaks at 1631, 1625, and 1619 cm –1 , respectively, which indicate the presence of the OH group in adsorbed water. − The peaks at 603 and 563 cm –1 of the HCL 2 spectrum and at 602 and 561 cm –1 of the HC and HCL 1 spectra refer to the bending mode of the phosphate (O–P–O) group. ,, Moreover, the adsorption bands that appeared in the range of 1027–1030 and 1100–1104 cm –1 represent the asymmetrical and symmetrical stretching modes of P–O and phosphate. , In addition, a duplex peak appeared at 1489 and 1379 cm –1 of HCL 1, which refers to the carbonate peak, which resulted due to the CO 2 adsorption by HAP . The band that appeared in the 450–550 cm –1 region can be assigned to the Ce–O stretching vibration. − Moreover, the adsorption peak observed in the 652 cm –1 region in the HCL 2 spectrum and the small peak that appeared in the 637 cm –1 region of the HCL 1 spectrum represent the vibrational mode of the La–O bond .…”

Section: Results and Discussionmentioning

confidence: 99%

Structure–Activity Relationship of Lanthanide-Incorporated Nano-Hydroxyapatite for the Adsorption of Fluoride and Lead

et al. 2021

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The growing demand for water purification provided the initial momentum to produce lanthanide-incorporated nano-hydroxyapatite (HAP) such as HAP·CeO2, HAP·CeO2·La(OH)3 (2:1), and HAP·CeO2·La(OH)3 (3:2). These materials open avenues to remove fluoride and lead ions from contaminated water bodies effectively. Composites of HAP containing CeO2 and La(OH)3 were prepared using in situ wet precipitation of HAP, followed by the addition of Ce(SO4)2 and La(NO3)3 into the same reaction mixture. The resultant solids were tested for the removal of fluoride and lead ions from contaminated water. It was found that the composite HAP·CeO2 shows fluoride and lead ion removal capacities of 185 and 416 mg/g, respectively. The fluoride removal capacity of the composite was improved when La(OH)3 was incorporated and it was observed that the composite HAP·CeO2·La(OH)3 (3:2) has the highest recorded fluoride removal capacity of 625 mg/g. The materials were characterized using scanning electron microscopy–energy-dispersive X-ray (SEM-EDX) spectrometry, Fourier transform infrared (FT-IR) spectrometry, X-ray powder diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), and Brunauer–Emmett–Teller (BET) surface area analysis. Analysis of results showed that Ce and La are incorporated in the HAP matrix. Results of kinetic and leaching analyses indicated a chemisorptive behavior during fluoride and lead ion adsorption by the composites; meanwhile, the thermodynamic profile shows a high degree of feasibility for fluoride and lead adsorption.

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On the Crystallization of Hydroxyapatite under Hydrothermal Conditions: Role of Sebacic Acid as an Additive

Cited by 47 publications

References 48 publications

Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair

Forsterite-hydroxyapatite composite scaffolds with photothermal antibacterial activity for bone repair

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

Structure–Activity Relationship of Lanthanide-Incorporated Nano-Hydroxyapatite for the Adsorption of Fluoride and Lead

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