In this paper, the results of the performance-based earthquake engineering (PBEE) analysis, carried out to assess the seismic behaviour of short-medium span steel-concrete composite Igirder bridges, are presented and discussed. The selected case study is part of a group of bridges analysed within the SEQBRI project, funded in 2012 by the European Union, which deals with a systematic development of the PBEE analysis for short-medium span steel-concrete compo-site I-girder bridges. In this respect, fragility and damage analysis of the selected bridge are performed using a proper component-based numerical model along with wide experimental campaign. These outcomes are then integrated in the decision-making analysis, where the selected decision variable is the repair cost ratio of the bridge. The results show the good performances of short medium span steel-concrete composite bridges, both for minor and major damage scenarios.