On the Cytoadhesion of<i>Plasmodium vivax</i>–Infected Erythrocytes

Carvalho, Bruna O.; Lopes, Stefanie Costa Pinto; Nogueira, Paulo Afonso; Orlandi, Patrícia Puccinelli; Bargieri, Daniel Youssef; Blanco, Yara C.; Mamoni, Ronei Luciano; Leite, Juliana Almeida; Rodrigues, Maurício M.; Soares, Irene S.; Oliveira, Tatiane Rodrigues de; Wunderlich, Gerd; Lacerda, Marcus Vinícius Guimarães; Portillo, Hernando A. del; Araujo, Maria Ophelia Galvāo de; Russell, Bruce; Suwanarusk, Rossarin; Snounou, Georges; Rénia, Laurent; Costa, Fábio T. M.

doi:10.1086/654815

Cited by 283 publications

(307 citation statements)

References 35 publications

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“…25 In addition, recent studies report cytoadherence of P. vivax-infected erythrocytes to endothelial receptors. 26 Furthermore, microrheologic research showed increased aggregation, agglutination, and reduction in deformability of P. vivax-infected erythrocytes. 27 Patients infected with P. vivax showed increased levels of interferon-γ and tumor necrosis factor showed a linear correlation with the possibility of developing severe malaria.…”

Section: Discussionmentioning

confidence: 99%

Maternal Clinical Findings in Malaria in Pregnancy in a Region of Northwestern Colombia

Piñeros

Tobón-Castaño

Álvarez

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. In malaria-endemic regions of Latin America, little is known about malaria in pregnancy. To characterize the clinical and laboratory findings of maternal infection, we evaluated 166 cases of pregnant women infected with Plasmodium spp. in a prospective study conducted in northwestern Colombia during [2005][2006]. A total of 89.8% (149 of 166) had fever or a history of fever in the past 48 hours, 9.0% (15 of 166) had severe malaria, of which 66.7% was caused by Plasmodium vivax and 33.3% by P. falciparum. Hepatic dysfunction was the main complication (9 of 15) observed. The proportion of severe cases was similar for both species (P = 0.41). In malaria-endemic areas of Colombia, malaria in pregnancy has a broad clinical spectrum. In pregnant women, P. vivax infection frequently leads to organspecific complications.

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Section: Discussionmentioning

confidence: 99%

Maternal Clinical Findings in Malaria in Pregnancy in a Region of Northwestern Colombia

Piñeros

Tobón-Castaño

Álvarez

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…Os valores de HT, HB e do número de eritrócitos foram menores apenas nos indivíduos com alta carga parasitária, o que já é conhecido e descrito na literatura 17,23 . Sabe-se que o aumento da carga parasitária pode acarretar diminuição no número de GV, devido à ruptura dessas células durante os ciclos assexuados, ao sequestro de hemácias infectadas pelo baço e à formação de rosetas 27,28,29 .…”

Section: Discussionunclassified

Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira

Costa

Tarragô

Garcia

et al. 2017

Revista Pan-Amazônica de Saúde

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“…Pregnant women are also more likely to experience relapses than non-pregnant ones [44]. P. vivax sequestration has been proposed [10], and recent reports indicate disproportional organ-specific and peripheral blood parasitaemia [42]. As for the dynamics of infection throughout pregnancy, no studies have addressed the issue.…”

Section: Dynamics Of Gestational and Placental Malariamentioning

confidence: 99%

“…In subsequent pregnancies, as immunity against placental-adherent strains develops, there is a reduced risk of adverse effects of malaria on the mother and fetus [6] and asymptomatic parasitaemia is common [7]. In the case of vivax malaria, with increasing reports of severe cases in Asia and South America [8,9], the consequences of infection during pregnancy remain to be elucidated, although adherence to endothelial cells [10] and sequestration of infected red blood cells in deep vasculature have been recently demonstrated [11,12].…”

Section: Introductionmentioning

confidence: 99%

Immune responses during gestational malaria: a review of the current knowledge and future trend of research

Maestre

Carmona‐Fonseca

2014

J Infect Dev Ctries

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Women pregnant with their first child are susceptible to severe P. falciparum disease from placental malaria because they lack immunity to placenta-specific cytoadherence proteins. In subsequent pregnancies, as immunity against placental parasites is acquired, there is a reduced risk of adverse effects of malaria on the mother and fetus and asymptomatic parasitaemia is common. In the case of vivax malaria, with increasing reports of severe cases in Asia and South America, the effects of infection by this species during pregnancy remain to be elucidated. This review summarized the main aspects involved in the acquisition of specific antimalarial immune responses during pregnancy with emphasis in research carried out in America and Asia, in order to offer a framework of interpretation for studies on pregnant women with malaria which are recently being produced in these regions. The authors conclude that (1) Effective humoral responses during gestational malaria are mainly directed against variant surface antigens codified by genes of the var2Csa family of P. falciparum; (2) Acquisition of immunity against these variant antigens depends on the degree and intensity of transmission, and the chance increases with age and successive pregnancies; (3) Antibody development is guided by specific cellular immune responses in cases of placental and maternal infection, and (4) The study of the significance of acquisition of specific immunity against both P. falciparum and P. vivax in America, should be performed.

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On the Cytoadhesion ofPlasmodium vivax–Infected Erythrocytes

Abstract: These observations prompt a modification of the current paradigms of the pathogenesis of malaria and clear the way to investigate the pathophysiology of P. vivax infections.

Cited by 283 publications

References 35 publications

Maternal Clinical Findings in Malaria in Pregnancy in a Region of Northwestern Colombia

Maternal Clinical Findings in Malaria in Pregnancy in a Region of Northwestern Colombia

Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira

Immune responses during gestational malaria: a review of the current knowledge and future trend of research

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