Among storage components, hard disk drives (HDDs) have become the most commonly-used type of nonvolatile storage due to their recent technological advances, including, enhanced energy efficacy and significantly-improved areal density. Such advances in HDDs have made them an inevitable part of numerous computing systems, including, personal computers, closed-circuit television (CCTV) systems, medical bedside monitors, and automated teller machines (ATMs).Despite the widespread use of HDDs and their critical role in real-world systems, there exist only a few research studies on the security of HDDs. In particular, prior research studies have discussed how HDDs can potentially leak critical private information through acoustic or electromagnetic emanations.Borrowing theoretical principles from acoustics and mechanics, we propose a novel denial-of-service (DoS) attack against HDDs that exploits a physical phenomenon, known as acoustic resonance. We perform a comprehensive examination of physical characteristics of several HDDs and create acoustic signals that cause significant vibrations in HDDs internal components. We demonstrate that such vibrations can negatively influence the performance of HDDs embedded in real-world systems. We show the feasibility of the proposed attack in two real-world case studies, namely, personal computers and CCTVs.