On the development of idiopathic subglottic stenosis

Damrose, Edward J.

doi:10.1016/j.mehy.2007.12.017

Cited by 63 publications

(65 citation statements)

References 12 publications

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“…The pathophysiology of the condition is unclear, but the age at diagnosis of approximately 50 years coincides with onset of menopause, supporting the hypothesis that hormones influence the etiologic process [1, 4, 11, 15]. It has been postulated that estrogen and progesterone influence the development of ISS, and a recent study has shown an imbalance between the estrogen receptors in patients with ISS.…”

Section: Discussionmentioning

confidence: 88%

Idiopathic subglottic stenosis: an epidemiological single-center study

Aarnæs

Sandvik

Brøndbo

2017

Eur Arch Otorhinolaryngol

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A retrospective epidemiological study of patients treated for idiopathic subglottic stenosis (ISS) during 2003–2013 at Oslo University Hospital, Rikshospitalet, was undertaken to assess its incidence, management and treatment outcomes. Out of a total of 123 patients with subglottic stenosis (84 female, 39 men), 38 patients were diagnosed with ISS, all of whom were female. Of these, 23 lived in the South-Eastern Norway Regional Health Authority, representing an incidence of 0.2 per 100,000 (95% CI 0.13–0.3) in this region of 2.9 million inhabitants. Mean age at diagnosis was 54 years (range 20–85 years), and the mean interval between symptom onset and diagnosis was 3.1 years. The 38 patients with ISS underwent a total of 132 operations between 2003 and 2013. All patients were managed endoscopically using laser surgery, with or without corticosteroids and Mitomycin C, with dilatation by balloon or bougie. Eight patients (21.1%) required only one procedure, while 30 patients (78.9%) had multiple operations. The median follow-up for all patients from the first operation was 5.3 years. The mean interval between procedures was 1 year for patients aged 20–48 years, 1.3 years for patients aged 49–61 years and 3.0 years for patients aged 62–85 years. No clinically significant complications were observed. In conclusion, the symptoms of ISS can be treated effectively with laser surgery and dilatation but the recurrence rate remains high and the time interval between operations does not increase with time, making ISS a continuing challenge.

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Section: Discussionmentioning

confidence: 88%

Idiopathic subglottic stenosis: an epidemiological single-center study

Aarnæs

Sandvik

Brøndbo

2017

Eur Arch Otorhinolaryngol

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“…Often patients with SGS endure a prolonged course of treatment involving endoscopic or open airway reconstruction. Some have undergone numerous endoscopic procedures in efforts to maintain airway patency and avoid a tracheostomy . Open airway procedures such as cricotracheal resection (CTR) have a high success rate in treating SGS, albeit with higher risks.…”

Section: Introductionmentioning

confidence: 99%

Effects of voice‐sparing cricotracheal resection on phonation in women

et al. 2016

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Introduction Individuals with idiopathic subglottic stenosis (SGS) are at risk for voice disorders prior to and following surgical management. This study examined the nature and severity of voice disorders in patients with SGS before and after a revised cricotracheal resection procedure designed to minimize adverse effects on voice function. Method Eleven women with idiopathic SGS provided presurgical and postsurgical audio recordings. Voice Handicap Index (VHI) scores were also collected. Cepstral, signal-to-noise, periodicity, and fundamental frequency analyses were undertaken for connected speech and sustained vowel samples. Listeners made auditory-perceptual ratings of overall quality and monotonicity. Results Paired samples statistical analyses revealed that mean fundamental frequency decreased from 215 Hz (SD=40 Hz) to 201 Hz (SD=65 Hz) following surgery. In general, VHI scores decreased after surgery. Voice disorder severity based on the cepstral spectral index of dysphonia™ for sustained vowels decreased (improved) from 41 (SD=41) to 25 (SD=21) points; no change was observed for connected speech. Semitone standard deviation (2.2 semitones) did not change from pre- to post-treatment. Auditory-perceptual ratings demonstrated similar results. Conclusions These preliminary results indicate that this revised cricotracheal resection procedure is promising in minimizing adverse voice effects while offering a longer-term surgical outcome for SGS. Further research is needed to determine causal factors for pretreatment voice disorders, as well as to optimize treatments in this population.

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“…Laryngotracheal stenosis (LTS) is a complex disease process arising from a diverse set of etiologies, including: intubation trauma, autoimmune disorders, radiation therapy, infection, congenital lesions, and idiopathic insults 1, 2. Treatment options for LTS are also diverse and may include the use of endoscopic surgery as well as open airway reconstruction 3, 4.…”

Section: Introductionmentioning

confidence: 99%