On the diagnostic features of the gas-discharge visualization for the assessment of medicines

Abstract

The therapeutic efficiency of medicines containing the same active ingredient depends on the production technology, as well as the excipients included in the tablet and the type of shell. In this work, we consider some of the possibilities of using the gas-discharge visualization method based on the phenomenon of channeling electrons through a liquid medium to study aqueous solutions of medicines. The study was carried out on the example of the passage of kilovolt electrons through drops of solutions of the beta-blocker bisoprolol, produced by various pharmacological companies. We studied bisoprolol preparations without excipients and bisoprolol preparations with excipients. The obtained differences in the characteristics of the gas-discharge luminescence for the studied medicines open up prospects for assessing the quality and pharmacological efficiency of medicines, and, subsequently, for the individualization of medicines therapy.