2020
DOI: 10.3389/fnins.2020.594612
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On the Digital Psychopharmacology of Valproic Acid in Mice

Abstract: Antiepileptic drugs (AEDs) require daily ingestion for maximal seizure prophylaxis. Adverse psychiatric consequences of AEDs present as: (i) reversible changes in mood, anxiety, anger and/or irritability that often necessitate drug discontinuation, and (ii) autism and/or cognitive/psychomotor delays following fetal exposure. Technical advances in quantifying naturalistic rodent behaviors may provide sensitive preclinical estimates of AED psychiatric tolerability and neuropsychiatric teratogenicity. In this stu… Show more

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Cited by 16 publications
(61 citation statements)
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“…Additionally, to be in line with animal welfare regulations 1 , the design of HCMS should crucially promote species-specific natural behavior. Whenever possible, such systems should be furnished with familiar bedding (Blom et al, 1996), chow and drinking water identical to those of vivarium conditions (Jankovic et al, 2019;Bass et al, 2020). Additionally, environmental enrichment by means of additional substrates and objects allows to expand the range of behaviors that the animals can express (Wolfer et al, 2004;Baumans, 2005).…”
Section: Benefits and Limitations Of A Home-cage Monitoring System What Makes A Cage A Home Cagementioning
confidence: 99%
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“…Additionally, to be in line with animal welfare regulations 1 , the design of HCMS should crucially promote species-specific natural behavior. Whenever possible, such systems should be furnished with familiar bedding (Blom et al, 1996), chow and drinking water identical to those of vivarium conditions (Jankovic et al, 2019;Bass et al, 2020). Additionally, environmental enrichment by means of additional substrates and objects allows to expand the range of behaviors that the animals can express (Wolfer et al, 2004;Baumans, 2005).…”
Section: Benefits and Limitations Of A Home-cage Monitoring System What Makes A Cage A Home Cagementioning
confidence: 99%
“…This may be related to infradian rhythms or the cumulative effects of social isolation itself. In one study employing PhenoTyper cages studying sociallyisolated C57BL/6J mice during an 8 day recording period, 1 www.na3rsc.org total daily distances gradually declined with similar gradual increases in total daily sleep (defined behaviorally) as well as feeding and licking times (Bass et al, 2020). Providing greater environmental enrichment may ameliorate such phenotypic drifts.…”
Section: Benefits and Limitations Of A Home-cage Monitoring System What Makes A Cage A Home Cagementioning
confidence: 99%
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