1971
DOI: 10.1113/jphysiol.1971.sp009646
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On the direct and crossed components of reflex responses to unilateral stimulation of the carotid body chemoreceptors in the dog

Abstract: SUMMARY1. In dogs under chloralose-urethane anaesthesia the chemoreceptors of the two carotid bodies were separately stimulated.2. The distribution of three primary reflex responses to carotid body stimulation was studied: parasympathetic bradycardia, sympathetic vasoconstriction, and increase in somatic phrenic nerve activity.3. The reflex bradyeardia evoked by either carotid body was mediated by both vagus nerves, but when either vagus was blocked a greater response could be obtained from the contralateral t… Show more

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Cited by 9 publications
(4 citation statements)
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“…Kaplan et al evidently had high chemoreceptor activity in their preparations, because sinus denervation resulted in a fall in mean blood pressure (see their Figs 2 and 3, also Table I) instead of the increase that usually occurs after bilateral carotid nerve sectioning (Heymans and Neil, 1958). Increased chemoreceptor activity in dogs leads to increased sympathetic tone to the blood vessels and a blood pressure rise (McQueen and Ungar, 1971). If our evidence that prostaglandins do not affect the baroreceptors directly is accepted, then the fall in blood pressure in the experiments of Kaplan et al can be explained by the reduction in chemoreceptor input to the central nervous system following the close arterial injection of PGE1 due to dilatation of carotid body blood vessels resulting in increased blood flow through the carotid body.…”
Section: Discussionmentioning
confidence: 99%
“…Kaplan et al evidently had high chemoreceptor activity in their preparations, because sinus denervation resulted in a fall in mean blood pressure (see their Figs 2 and 3, also Table I) instead of the increase that usually occurs after bilateral carotid nerve sectioning (Heymans and Neil, 1958). Increased chemoreceptor activity in dogs leads to increased sympathetic tone to the blood vessels and a blood pressure rise (McQueen and Ungar, 1971). If our evidence that prostaglandins do not affect the baroreceptors directly is accepted, then the fall in blood pressure in the experiments of Kaplan et al can be explained by the reduction in chemoreceptor input to the central nervous system following the close arterial injection of PGE1 due to dilatation of carotid body blood vessels resulting in increased blood flow through the carotid body.…”
Section: Discussionmentioning
confidence: 99%
“…The possibility exists that, during BCO, the fall in carotid sinus pressure might, by reducing carotid body blood flow, lead to stimulation of the carotid body chemoreceptors. This would be liable to cause reflex sympathetic vasoconstriction (McQueen & Ungar, 1971), and the pressor response to BCO might, therefore, be attributed partly to withdrawal of inhibitory baroreceptor activity and partly to chemoreceptor stimulation. Carotid chemoreceptor stimulation did seem to occur during BCO in control rats since respiration increased, albeit rather variably, when the animals were breathing air, but to a lesser extent when breathing 100% 02, a condition in which chemoreceptor activity is greatly reduced.…”
Section: Baroreceptor Reflexmentioning
confidence: 99%
“…Each area postrema, like each carotid body (McQueen & Ungar, 1971), can influence both vagi and the medullary reticular formation , implying decussation at some level. The site at which decussation occurs is uncertain although Calaresu & Thomas (1971) have suggested an integrative function for the paramedian reticular nucleus involving the sympathetic and parasynipathetic outflow.…”
Section: Discussionmentioning
confidence: 99%