On the Duration of Life of the Red Blood Corpuscles

Schiødt, E.

doi:10.1111/j.0954-6820.1938.tb16072.x

Cited by 25 publications

(2 citation statements)

References 44 publications

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“…Direct models are based on the theory for transfused RBCs developed early on [7, 9, 14, 60]. Some quantitative descriptions developed later focused on fitting a curve to the survival curve and quantifying the mean lifespan and half-life [7, 8, 17, 24, 32, 65].…”

Section: Introductionmentioning

confidence: 99%

Models for the red blood cell lifespan

Shrestha¹,

Horowitz

Hollot

et al. 2016

J Pharmacokinet Pharmacodyn

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The lifespan of red blood cells (RBCs) plays an important role in the study and interpretation of various clinical conditions. Yet, confusion about the meanings of fundamental terms related to cell survival and their quantification still exists in the literature. To address these issues, we started from a compartmental model of RBC populations based on an arbitrary full lifespan distribution, carefully defined the residual lifespan, current age, and excess lifespan of the RBC population, and then derived the distributions of these parameters. For a set of residual survival data from biotin-labeled RBCs, we fit models based on Weibull, gamma, and lognormal distributions, using nonlinear mixed effects (NLME) modeling and parametric bootstrapping. From the estimated Weibull, gamma, and lognormal parameters we computed the respective population mean full lifespans (95% confidence interval): 115.60 (109.17–121.66), 116.71 (110.81–122.51), and 116.79 (111.23–122.75) days together with the standard deviations of the full lifespans: 24.77 (20.82–28.81), 24.30 (20.53–28.33), and 24.19 (20.43–27.73). We then estimated the 95th percentiles of the lifespan distributions (a surrogate for the maximum lifespan): 153.95 (150.02–158.36), 159.51 (155.09–164.00), and 160.40 (156.00–165.58) days, the mean current ages (or the mean residual lifespans): 60.45 (58.18–62.85), 60.82 (58.77–63.33), and 57.26 (54.33–60.61) days, and the residual half-lives: 57.97 (54.96–60.90), 58.36 (55.45–61.26), and 58.40 (55.62–61.37) days, for the Weibull, gamma, and lognormal models respectively. Corresponding estimates were obtained for the individual subjects. The three models provide equally excellent goodness-of-fit, reliable estimation, and physiologically plausible values of the directly interpretable RBC survival parameters.

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Section: Introductionmentioning

confidence: 99%

Models for the red blood cell lifespan

Shrestha¹,

Horowitz

Hollot

et al. 2016

J Pharmacokinet Pharmacodyn

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“…E Schiødt used various methods to estimate the longevity of erythrocytes in 1938, stating: ‘Investigations into the duration of life of the blood corpuscles date far back in the history of physiology, as the question is of the greatest importance to the estimation of the value of blood transfusion’ . By determining the excretion of bilirubin into the bile, he found that the lifetime of red blood cells was 30 days under normal conditions.…”

Section: Renal Anaemia and The Lifespan Of Erythrocytesmentioning

confidence: 99%

Searching the haematology and inflammation archives ofJournal of Internal Medicine

Palmblad

Kimby

2013

J Intern Med

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The life‐span of the red cell in man

Callender¹,

Powell²,

Witts³

1945

J. Pathol.

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%Emethods which have been applied to the determination of the life-span of red cells have so far given altogether discordant results and the rationale of every one of them is of more or less questionable validity. Many bibliographies of the subject are available ; Schinrdt (1938) gives a useful collection of references which, though neither exhaustive nor up-to-date, exemplifies shortly the various techniques and numerical results. Our object in this paper is to present data on the course of destruction of erythrocytes after transfusion into normal subjects, as determined by the differential agglutination method of Ashby (1919). We shall show that from them, under certain assumptions, it is possible to calculate not merely the average life of the cells as they occur naturally, but also their chance of survival for any length of time.

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On the Duration of Life of the Red Blood Corpuscles

Cited by 25 publications

References 44 publications

Models for the red blood cell lifespan

Models for the red blood cell lifespan

Searching the haematology and inflammation archives ofJournal of Internal Medicine

The life‐span of the red cell in man

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