On the Elimination of Nitrogen, Sulphates, and Phosphates After the Ingestion of Proteid Food

Sherman, H. C.; Hawk, P. B.

doi:10.1152/ajplegacy.1900.4.1.25

Cited by 8 publications

(9 citation statements)

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“…The extra supply of single well-defined portions of animal flesh to the basal regimen did proportionally increase the postprandial excretion of N and S values. The authors concluded that the excretion of S "ran closely parallel to that of N both on the normal days and on those affected by the extra ingestion of protein" [63]. Working along the same lines are the kinetic investigations using diets enriched with 13 C-Met showing that the obligatory Met losses correlate with those predicted from obligatory N-losses [64].…”

Section: The Sulfur-deficiency Concept: Histori-cal Backgroundmentioning

confidence: 84%

“…To our knowledge, the first demonstration that N and S metabolisms are tightly interwoven was provided more than a century ago by 2 US investigators who defined themselves as enjoying an "uniform and perfectly normal condition of nutrition" [63]. The authors experienced the metabolic fate of a balanced diet providing 15 g N and 2,600 Kcal/day.…”

Section: The Sulfur-deficiency Concept: Histori-cal Backgroundmentioning

confidence: 99%

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Hyperhomocysteinemia is a Biomarker of Sulfur-Deficiency in Human Morbidities~!2009-10-03~!2009-11-18~!2009-12-22~!

Ingenbleek¹

2010

TOCCHEMJ

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Methionine (Met) is crucially involved in the synthesis of S-compounds endowed with molecular, structural and functional properties of survival value. Dietary Met may undergo transmethylation processes to release homocysteine (Hcy) which may either be regenerated to Met following remethylation (RM) pathways or catabolized along the transsulfuration (TS) cascade. The activity of enzymes governing RM and TS pathways is depending on pyridoxine, folate and cobalamin bioavailability. Dietary restriction in any of these watersoluble B-vitamins may lead to hyperhomocysteinemia (HHcy) causing a panoply of cardiovascular disorders. Taken together, the vitamin triad only affords partial account of Hcy variance, prompting the search for additional causal factor(s). Body composition studies demonstrate that nitrogen (N) and sulfur (S) maintain tightly correlated concentrations in tissues of both healthy subjects and diseased patients. Any morbid condition characterized by insufficient N intake or assimilation, as seen in protein malnutrition or intestinal malabsorption, reduces body S accretion rates. Excessive urinary N-losses, as reported in acute or chronic inflammatory disorders, entail proportionate obligatory S-losses. As a result, lean body mass (LBM) undergoes downsizing and concomitant depletion of N and S body stores which depresses the activity of cystathionine--synthase, thereby promoting upstream accumulation of Hcy and overstimulation of RM processes. HHcy thus appears as the dark side of efforts developed by S-deprived patients to safeguard Met homeostasis. Irrespective of vitamin-B status, Hcy values are negatively correlated with LBM shrinkage well identified by the serial measurement of plasma transthyretin (TTR). The Sdeprivation theory fulfills the gap and allows full causal coverage of the metabolic anomaly, hence providing together with vitamin-deficiencies an unifying overview of the main nutritional determinants implicated in HHcy epidemiology.

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Section: The Sulfur-deficiency Concept: Histori-cal Backgroundmentioning

confidence: 84%

Section: The Sulfur-deficiency Concept: Histori-cal Backgroundmentioning

confidence: 99%

Hyperhomocysteinemia is a Biomarker of Sulfur-Deficiency in Human Morbidities~!2009-10-03~!2009-11-18~!2009-12-22~!

Ingenbleek¹

2010

TOCCHEMJ

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“…Several investigations have documented the close relationship linking the amount of N and/or S intakes and the degree of sulfaturia, confirming the pioneer study performed a century ago (Sherman & Hawk, 1900). Adult volunteers given three different levels of protein intake excrete in their urinary output SO 4 ‫מ2‬ values highly correlated (r 0·88) with dietary N intake (Wright et al 1960).…”

Section: ‫מ2‬mentioning

confidence: 67%

“…The first investigation correlating N and S compounds in healthy human subjects was described by Sherman & Hawk (1900). The authors investigated the metabolic consequences of a 7 d period resulting from 'the ingestion of a rather large quantity of protein food when the body is kept in a uniform and perfectly normal condition of nutrition'.…”

Section: Refractoriness Of Sulfur-containing Molecules To Dietary Manmentioning

confidence: 99%

“…2. Evolutionary pattern of a 7 d N and S balance study (Sherman & Hawk, 1900). Baseline values are normalised to 100 % and result from the daily intake by two healthy subjects (the authors of the publication themselves) of a standard regimen providing 10·9 MJ(2600 kcal) and 15 g N. The curves shown here represent the relative fluctuations in the average rates of excretion of N (--) and of S (---).…”

Section: Regulation Of Methionine Homeostasis In Proteindepleted Statesmentioning

confidence: 99%

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The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinaemia

Ingenbleek¹,

Young

2004

Nutr. Res. Rev.

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N and S metabolisms are closely interwoven throughout both the plant and animal kingdoms. The essentiality of S relates to its participation in the structure of S-containing amino acids (SAA), to its inclusion in many sulfonated molecules, and to a myriad of metabolic and catalytic reactions of vital importance. Methionine (Met) is the indispensable SAA supplied by food proteins and its plasma homeostasis is achieved via a number of highly efficient regulatory mechanisms. In all conditions characterised by a negative body protein balance such as in dietary restriction or cytokine-induced hypercatabolic losses, N and S endogenous pools manifest parallel tissue depletion rates. Adaptive conservation of N and S body stores is reached by a functional restraint of the trans-sulfuration cascade, through the depression of cystathionine ␤-synthase activity. As a result, upstream accumulation of homocysteine favours its re-methylation conversion to Met which helps maintain metabolic pathways of survival value. In addition to the measurement of vitamin indices, that of plasma transthyretin, a sensitive marker of protein nutritional status, is proposed to identify the fluctuations of the total body N component accountable for the alterations of homocysteine concentrations in body fluids.

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Plasma Transthyretin Reflects the Fluctuations of Lean Body Mass in Health and Disease

Ingenbleek¹

2009

Recent Advances in Transthyretin Evolution, Structure and Biological Functions

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On the Elimination of Nitrogen, Sulphates, and Phosphates After the Ingestion of Proteid Food

Cited by 8 publications

References 0 publications

Hyperhomocysteinemia is a Biomarker of Sulfur-Deficiency in Human Morbidities~!2009-10-03~!2009-11-18~!2009-12-22~!

Hyperhomocysteinemia is a Biomarker of Sulfur-Deficiency in Human Morbidities~!2009-10-03~!2009-11-18~!2009-12-22~!

The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinaemia

Plasma Transthyretin Reflects the Fluctuations of Lean Body Mass in Health and Disease

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