The tribological properties of Al-Li alloys impact the reliability of components used in different industrial sectors. In this research, the effect of normal load on friction and wear properties of the extruded spray-formed 2195-T6 Al-Li alloy is investigated by using a pin-on-disk tester. Through the microstructure of the friction subsurface, it is evaluated that the friction coefficient of 2195 alloy decreases from 0.408 to 0.306 by increasing load (25N to 150N), while the wear rate increases exponentially. It is also analyzed that a mild-severe wear transition occurs between 100N and 125N and the main wear mechanism gradually shifts from abrasive wear and oxidative wear to delamination wear (25N~100N), and finally attains the state of severe plastic deformation (125N~150N). Under the action of normal load and friction shearing force, the deformation layer in the subsurface increases from 3μm to 43μm with increasing load, and the accumulation of strain leads to cracks and holes.