On the Estimation of Heritability with Family-Based and Population-Based Samples

Kim, Youngdoe; Lee, Young; Lee, Sungyoung; Kim, Nam Hee; Lim, Jeongmin; Kim, Young Jin; Oh, Ji Hee; Min, Hyun Jin; Lee, Meehee; Seo, Hyeon-Jeong; Lee, SoHyun; Sung, Joohon; Cho, Nam H.; Kim, Bong-Jo; Han, Bok‐Ghee; Elston, Robert C.; Won, Sungho; Lee, Juyoung

doi:10.1155/2015/671349

Cited by 19 publications

(18 citation statements)

References 22 publications

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“…In addition, we selected EBV VCA‐IgA, given its reported familial correlations, 21 to estimate its heritability and to adjust VCA‐IgA levels as an additional covariate for heritability estimates of NP EBV loads. For height and body mass index (BMI) the heritability was estimated as well to verify the validity of these analyses given their reported high heritability and the multiple identified genetic susceptibility variants 22‐24 …”

Section: Methodsmentioning

confidence: 99%

Nasopharyngeal Epstein‐Barr virus DNA loads in high‐risk nasopharyngeal carcinoma families: Familial aggregation and host heritability

Miao

Wang

Liao

et al. 2020

Journal of Medical Virology

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Nasopharyngeal carcinoma (NPC), the most common head and neck cancer, is characterized by distinct geographic distribution and familial aggregation. Multiple risk factors, including host genetics, environmental factor, and EBV infection, have been linked to the development of NPC, particularly in the familial clustering cases. However, the cause of NPC endemicity remains enigmatic due possibly to the complicated interplay between these risk factors. Recently, positive Epstein‐Barr virus (EBV) DNA loads at nasopharyngeal (NP) cavity has been found to reflect NPC development and applied in NPC screening. To examine whether the increased NP EBV loads could aggregate in the families and be affected by host genetics and environmental factor, EBV loads were obtained by 510 NP brushing samples from eligible unaffected individuals, who have two or more relatives affected with NPC, in 116 high‐risk NPC families. The correlation of relative pairs was estimated using S.A.G.E. (version 6.4, 2016), and host heritability of NP EBV loads was calculated with variance component models using SOLAR (version 8.4.2, 2019). In result, significant correlations of EBV loads were observed between parent‐offspring pairs and sibling‐sibling pairs (P < .001), but not in distant kin relationship pairs. Interestingly, after excluding the shared environmental factor within families, host genetics contributes significantly to NP EBV loads with a heritability of 56.41% (P = 1.00 × 10−7), and its effect was slightly elevated (68.86%, P = 3.40 × 10−6) in families with more NPC cases (≥3). These findings indicate that additional host‐genetic variants involved in the EBV local NP mucosal behavior may be especially important for the development of NPC.

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Section: Methodsmentioning

confidence: 99%

Nasopharyngeal Epstein‐Barr virus DNA loads in high‐risk nasopharyngeal carcinoma families: Familial aggregation and host heritability

Miao

Wang

Liao

et al. 2020

Journal of Medical Virology

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“…Polygenic variance is estimated using the kinship coefficient matrix, using the same mathematical principles as recently developed heritability estimation methods for unrelated subjects (Yang et al, 2010). A further description of these methods can be found in Kim et al (2015). Thus, we used structural equation modelling (SEM) to partition spelling at each age level into heritable components, random environmental components, and the influence of SES.…”

Section: Methodsmentioning

confidence: 99%

Heritability and longitudinal outcomes of spelling skills in individuals with histories of early speech and language disorders

Lewis

Freebairn

Tag

et al. 2018

Learning and Individual Differences

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This study examined the spelling skills in middle childhood and adolescence in individuals with histories of early childhood speech sound disorders (SSD) with and without language impairment (LI). Youth without such histories were also included (No SSD/LI group). The heritability of spelling skills at each age level was estimated. Children with SSD were classified as SSD-only, SSD with LI but without childhood apraxia of speech (SSD + LI/ No CAS), and CAS and LI (CAS + LI). The SSD-only group did not differ in spelling from the No SSD/LI group, suggesting that SSD-only did not increase risk for poor spelling. The SSD + LI/No CAS and CAS + LI groups had poorer spelling skills than the SSD-only and No SSD/LI groups. Spelling was associated with phonological awareness in the middle childhood and adolescent samples and with rapid automatized naming in the adolescent sample. Heritability of spelling skills was stronger in adolescence than in middle childhood. Differences in the correlates of spelling and in heritability at the two ages suggest developmental changes in the factors contributing to spelling.

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“…Because the twin study that reported 88.5% heritability of measles vaccination response was from the same Rochester, MN, community as the population-based sample used in this study, large environmental differences are not likely to explain the difference in heritability estimates. It is known, however, that twin studies can give inflated estimates of heritability when twins share more environment than distantly related subjects [33]. This raises the question of whether the earlier twin study overestimated the heritability of response to measles vaccination.…”

Section: Discussionmentioning

confidence: 99%

Heritability of vaccine-induced measles neutralizing antibody titers

Schaid

Haralambieva

Larrabee

et al. 2017

Vaccine

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Understanding how genetics influences inter-individual variation of antibody titers in response to measles vaccination is vital to understanding possible sources of vaccine failure as well as improved vaccine development. Although it is recognized that both the human leukocyte antigen (HLA) genes and the immunoglobulin allotype genes play significant roles in immune response, there is significant variation in antibody titers that is not explained by these genes. To obtain a more complete estimate of the role of the entire genome, we used a large panel of single nucleotide polymorphisms to estimate the heritability of antibody response to measles vaccine. Based on 935 subjects with European ancestry, we estimated the heritability to be 49% (standard error 0.17). We also estimated the heritability attributable to each chromosome, and found a large range in chromosome-specific heritabilities. Notably, chromosome 1 had the largest estimate (28%), while chromosome 6, which harbors HLA, had an estimated heritability of 13%. Compared with a prior study of twins in the same community, which resulted in a heritability estimate of 88.5%, our study suggests there are either many rare genetic variants, or many common genetic variants of small effect sizes that contribute to variations of antibody titers in response to measles vaccine.

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On the Estimation of Heritability with Family-Based and Population-Based Samples

Cited by 19 publications

References 22 publications

Nasopharyngeal Epstein‐Barr virus DNA loads in high‐risk nasopharyngeal carcinoma families: Familial aggregation and host heritability

Nasopharyngeal Epstein‐Barr virus DNA loads in high‐risk nasopharyngeal carcinoma families: Familial aggregation and host heritability

Heritability and longitudinal outcomes of spelling skills in individuals with histories of early speech and language disorders

Heritability of vaccine-induced measles neutralizing antibody titers

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