On the Etiology of the Stein-Leventhal Syndrome

Leon, N.; Beçak, Willy; Beçak, Maria Luiza; Ri, Dorfman

doi:10.1159/000151806

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…Chromosomal anomalies have also been met with, later on, by other researchers. Leon et al (1963) have observed a normal feminine karyotype in one case, and a pattern X X / X X Y in another case; Bishun and Morton (1964) have noted a feminine karyotype in two cases, the pattern X X / X X D in one, and a probable pattern X O / X X in another; and finally Hargrave (1965) has observed a pattern X O / X X in only one case.…”

Section: Physical Observationsmentioning

confidence: 97%

Stein-Leventhal Syndrome in Sisters — The Possible Role of Genetic Factors in the “Polycystic Ovary Syndrome”

Borghi

Maiello

Giusti

1972

Acta genet. med. gemellol.

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SummaryTwo pairs of sisters are reported who showed clinical, morphologic, and hormone abnormalities, such as to be classified in the picture of the so-called Stein-Leventhal syndrome.These cases, as other few similar observations, may suggest the possibility that, at least in some instances, the Stein-Leventhal syndrome can be governed by factors of a genetic order.After a short review of the literature on this subject, it is pointed out that enough evidence supports the existence of predisposing genetic factors to the manifestation of the syndrome, although a true heredity of the disease cannot at the moment be entirely supported. Also some fraternal cases could find an explanation in lesional actions repeated during subsequent pregnancies.

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