On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies

Lekki, Janusz; Stachura, Z.; Dabroś, W; Stachura, Jerzy; Menzel, F.; Reinert, Tilo; Butz, T.; Pallon, Jan; Gontier, Étienne; Ynsa, M.D.; Moretto, Philippe; Kertész, Zsófia; Szikszai, Zita; Kiss, Á.Z.

doi:10.1016/j.nimb.2007.02.021

Cited by 58 publications

(41 citation statements)

References 6 publications

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“…Thus, skin penetration of TiO 2 was investigated in vitro with intact skin and with stripped skin as a model of injured skin. Previous reports have indicated that hair follicles are important in the skin penetration of nanoparticles (Lekki et al, 2007;Zvyagin et al, 2008). Therefore, hair-removed skin was used to represent skin damaged by hair-removal treatments often done for the pursuit of beauty.…”

Section: Skin Penetration Of Tiomentioning

confidence: 99%

Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro

et al. 2010

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-It is important for toxicological assessment of nanoparticles to determine the penetration of nanoparticle in skin qualitatively and quantitatively. Skin penetration of four different types of rutile titanium dioxide (TiO 2 ) (T-35, 35 nm, non-coating; TC-35, 35 nm, with almina/silica/silicon coating; Tdisp, 10 x 100 nm, mixture of almina coated and silicon coated particles, dispersed in cyclopentasiloxan; T-250, 250 nm, non-coating) was determined with in vitro intact, stripped, and hair-removed skin of Yucatan micropigs to study the effect of dispersion and skin conditions. The TiO 2 was suspended in a volaapplied at a dose 2 μl/cm 2 for 24 hr, followed by cyanoacrylate stripping. The Ti concentration in skin was determined by ICP-MS. T-35 and T-250 easily aggregated in suspension with a mean diameter greater than 1 μm. TC-35 and T-disp showed good dispersion properties with a mean diameter in suspension of approximately 100 nm. No penetration was observed regardless of TiO 2 type in intact and stripped skin.SEM-EDS observation showed that Ti penetrated into vacant hair follicles (greater than 1 mm below the skin surface), however, it did not penetrate into dermis or viable epidermis.

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Section: Skin Penetration Of Tiomentioning

confidence: 99%

Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro

et al. 2010

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“…We predict that X-ray scanning analytical microscopy will be a useful method for studying biodistribution of micro-and nano-sized particles, because this method requires no labeling or treatment of the target particles [413]. [411,[418][419][420]. As an example, visualization of the penetration of sunscreen formulations containing TiO 2 NPs (about 20 nm primary particle size) into hair follicles of both human and porcine skin using these complementary methods of ion microscopy (PIXE, RBS, STIM) showed that the NPs were found as deep as approx.…”

Section: Ion Beam Analysis Techniquesmentioning

confidence: 99%

“…As an example, visualization of the penetration of sunscreen formulations containing TiO 2 NPs (about 20 nm primary particle size) into hair follicles of both human and porcine skin using these complementary methods of ion microscopy (PIXE, RBS, STIM) showed that the NPs were found as deep as approx. 400 µm in the follicle, obviously introduced mechanically rather than by a diffusive process ( Figure 10) [418]. Figure 10 here Figure 10 shows a sagittal cut through a hair follicle of porcine skin which was exposed to an isopropylmyristate gel containing TiO 2 NPs and subsequently washed with water.…”

Section: Ion Beam Analysis Techniquesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…The accurate concentration of the chemical elements requires the determination of the initial mass of the sample done by STIM analysis [411, 418 -420] . As an example, the visualization of the penetration of sunscreen formulations containing TiO 2 NPs (about 20 nm primary particle size) into hair follicles of both the human and porcine skin using these complementary methods of ion microscopy (PIXE, RBS, STIM) showed that the NPs were found as deep as approximately 400 μ m in the follicle, obviously introduced mechanically rather than by a diffusive process ( Figure 10 ) [418] . Figure 10 shows a sagittal cut through a hair follicle of porcine skin that was exposed to an isopropylmyristate gel containing TiO 2 NPs and subsequently washed with water.…”

Section: Ion Beam Analysis Techniquesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies

Cited by 58 publications

References 6 publications

Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro

Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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