On the function of pentadecanoic acid and docosahexaenoic acid during culturing of the thraustochytrid, Aurantiochytriumsp. NB6-3

Abstract

Aurantiochytrium sp., a marine thraustochytrid with a high growth rate, has two fatty acid synthesis path ways [1]. One pathway contains the fatty acid synthase and is used for the synthesis of saturated fatty acids, whereas the other pathway contains the polyketide synthase without desaturases and is used for the synthesis of polyunsaturated fatty acid. Pentadecanoic acid (C15) and palmitic acid (C16), and docosahexaenoic acid (DHA) are major fatty acids of thraustochytrids including Aurantiochytrium [2]. The saturated fatty acids C15 and C16 are synthesized by the pathway containing fatty acid synthase, whereas DHA is synthesized by the pathway containing polyketide synthase, respectively. In living cells, the fatty acid moiety of triglycerides is used for energy production through the formation of acetyl-CoA by -oxidation. From even-numbered fatty acids (EFAs), only acetyl-CoA is formed by -oxidation, whereas from odd-numbered fatty acids (OFAs) such as C15, acetyl-CoA and propionyl-CoA are formed. Although they have some biological function, OFAs are unusual fatty acids. The hair glowing effect of C15-monoglyceride, which was

An acidic morpholine derivative containing glyceride from thraustochytrid, Aurantiochytrium

“…The thraustochytrid Aurantiochytrium has been examined extensively as a producer of high contents of squalene, docosahexaenoic acid (DHA) and pentadecanoic acids as an odd-carbon chain fatty acid [1][2][3][4] . It is well known that the major lipids of Arantiochytrium are comprised of squalene, carotenoids, triglyceride, glycolipids and phospholipids [5][6][7][8] .…”