On the fundamental nature of vitamin D action

McGowan, John; Cunningham, Ira James; Auchinachie, Douglas William

doi:10.1042/bj0251295

Cited by 13 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The peculiar circumstances attending the performance of such experiments in regard to the starvation during the experimental period, as has just been discussed, make it possible to derive the same conclusions, as have been arrived at in the present instance, also from the results obtained in the preliminary investigation [McGowan et al, 1931], where urinary samples alone were analysed.…”

supporting

confidence: 74%

“…IN a preliminary paper [McGowan, Cunningham and Auchinachie, 1931] certain tentative conclusions were drawn, on the basis of incomplete balance experiments, regarding the intrinsic and essential nature of vitamin D action. A series of complete calcium and phosphorus balance experiments has since been carried out, and these are dealt with in this paper.…”

mentioning

confidence: 99%

“…One recognises the fallacy underlying any attempt, under the circumstances of the stagnation of the intestinal contents etc., to place reliance on this ground alone on the percentage figures of " shift " as given in the Tables; but if one compares the absolute amounts of P205 ini the urine of the animals in the experimental periods with that in their urine in the pre-period andwith that in the urine of a healthy rabbit in a similar grade of starvation, one is on much firmer ground, and the figures for the "shift" become significant. In the first case, when the pre-period and experimental period are compared, in spite of the fact that practically no food is being taken in the experimental period, the absolute amount of P20r in the urine is greatly, sometimes enormously, increased; while, in the second case of equal degree of starvation (though not necessarily of equal degree of want of absorption from the intestines in the case of the "healthy" rabbit), the amount of P206 excreted in the urine of the "healthy" starved rabbit is only a small fraction of that excreted by those poisoned with vitamin D. Only one conclusion would seem to be valid under the circumstances, namely that the excess P.05 in the animals poisoned with vitamin D must be of endogenous origin, and it has already been suggested [McGowan et al, 1931] that its source is the lipins of the body which are broken down under the influence of the vitamin D. It should be noted also that the amount of P205 actually passing by the urine does not give an exact criterion of the extent of this splitting up, for a considerable amount of the phosphorus, so formed, is fixed in the tissues of the body in an insoluble form in the various "calcifications. "…”

mentioning

confidence: 99%

See 2 more Smart Citations

Further investigations into the fundamental nature of vitamin D action

McGowan¹

1933

Biochemical Journal

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 74%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Further investigations into the fundamental nature of vitamin D action

McGowan¹

1933

Biochemical Journal

Self Cite

View full text Add to dashboard Cite

“…McGowan, Cunningham & Auchinachie (1931) suggest that it primarily attacks the lipids of the tissues with the liberation of phosphoric acid, the lack of which in the blood is a notable feature of rickets. It also prevents the loss of calcium by the bowel by causing its deposition as phosphate.…”

Section: Nutrition and Teeth 55mentioning

confidence: 99%

Nutrition and the teeth

Mellanby

Wilkinson²

1959

Proc. Nutr. Soc.

View full text Add to dashboard Cite

The fact that this Symposium has been arranged to discuss the way in which the food .~ we take can influence the development and calcification of our teeth is an indication that there are still many gaps in our knowledge. It is a subject that has attracted many research workers and a mere review of all the work that has been done on this highly complex problem would fill several volumes. I n a short paper I can only attempt to deal with a limited field and record in a few words the results of work that may have taken months or years of arduous labour and much imaginative thought.The human species is not a good medium to use for any controlled experiments, especially when they have to be carried on over a long period of time, and most of the knowledge we have regarding the effect of various diets upon the calcification of bones and teeth is the result of investigations carried out upon animals that develop more quickly and can be killed at the appropriate time and so provide an opportunity for a detailed examination of the tissue being investigated. There is, however, a good deal of evidence that often the results obtained in one species are not valid for another and a good deal of caution must be exercised in applying the results of animal experiments to the human race and in assuming that the reactions would be the same. In spite of the volume of work that has been done and the valuable information gained from animal experiments, we have little definite knowledge regarding the way in which calcification in man is affected by the various factors in his diet, and when I settled down to the task of trying to present a picture of it I found myself with a very large canvas but very little paint.It is generally agreed that once teeth are calcified and erupted into the mouth the enamel is capable of little change and any effect diet may have upon the breakdown of enamel, as found in that ubiquitous disease dental caries, must be due to local action in the mouth rather than to any effect it may have as the result of metabolism in the body. The way, however, in which enamel is destroyed by local factors, such as food, saliva and the organisms they support, is still far from being understood but, whatever the line of attack, I think it is reasonable to assume that the resistance of a tooth to any attack will be influenced by the way it has developed and the extent to which calcification has taken place. It is to those factors in the diet that are more specifically related to calcification that I propose referring in this paper. 54

show abstract

Die Vitamine

Willstaedt¹

1935

Klin Wochenschr

View full text Add to dashboard Cite

On the fundamental nature of vitamin D action

Cited by 13 publications

References 1 publication

Further investigations into the fundamental nature of vitamin D action

Further investigations into the fundamental nature of vitamin D action

Nutrition and the teeth

Die Vitamine

Contact Info

Product

Resources

About