This paper investigates the brane-localized interactions, including DGP gravity and higher derivative (HD) gravity localized on the brane. We derive the effective action on the brane, which suggests the brane-localized HD gravity suffers the ghost problem generally. Besides, we obtain novel algebraic identities of the mass spectrum, which reveal the global nature and can characterize the phase transformation of the mass spectrum. We get a powerful ghost-free condition from the spectrum identities, which rules out one type of brane-localized HD gravity. We further prove the mass spectrum is real and non-negative m2 ≥ 0 under the ghost-free condition.Furthermore, we discuss various constraints on parameters of brane-localized gravity in AdS/BCFT and wedge holography, respectively. They include the ghost-free condition of Kaluza-Klein and brane-bending modes, the positive definiteness of boundary central charges, and entanglement entropy. The ghost-free condition imposes strict constraint, which requires non-negative couplings for pure DGP gravity and Gauss-Bonnet gravity on the brane. It also rules out one class of brane-localized HD gravity. Thus, such HD gravity should be understood as a low-energy effective theory on the brane under the ghost energy scale. Finally, we briefly discuss the applications of our results.