On the growth mechanisms of nanoemulsions

Nazarzadeh, Elijah; Anthonypillai, Tania; Sajjadi, Shahriar

doi:10.1016/j.jcis.2012.12.018

Cited by 117 publications

(100 citation statements)

References 42 publications

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“…8; PSD broadening can be attributed to coalescence whereas PSD sharpening is a result of Ostwald ripening. 8 In the rst 24 h, a gradual shi of bimodal size distribution to monomodal distribution towards higher droplet size through the expense of smaller droplets was observed. And then the particle distribution broadened with time, associated with the rise in the droplet size.…”

Section: Stabilitymentioning

confidence: 91%

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Development and characterization of promising Cremophor EL-stabilized o/w nanoemulsions containing short-chain alcohols as a cosurfactant

2017

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Nanoemulsions have attracted much attention due to their wide application in commercial industries such as pharmaceutics, food, beverages and skin care. Cremophor EL has been extensively used for emulsification, protection and solubilization of various lipophilic bioactive agents. However, their anaphylactoid hypersensitivity reactions are still challenging. Therefore, the aim of this study was to develop and characterize a promising, low-level Cremophor EL-stabilized o/w nanoemulsion using the spontaneous emulsification method for oral administration. From comparing the physicochemical properties (particle size and size distribution) of their emulsions, Cremophor has better emulsifying capacity than Tween and the droplet radius of emulsions can be reduced by increasing the surfactant concentration in current systems. The impact of various short-chain alcohols (C-OH < 5) on the formation and stability of nanoemulsions was also investigated to optimize the formulations. And there is a good correlation between nanoemulsion droplet size and the surfactant packing parameter (p). The smallest droplet size with the narrowest size distribution was produced by the system containing ethylene glycol as a cosurfactant. However, preparation of nanoemulsions with ethylene glycol was a time-consuming process since it was difficult to emulsify the water-induced gel-structure. Surfactantto-oil mass ratio and surfactant-to-cosurfactant levels had to be optimized to produce fine droplets.Moreover, there was a linear relationship between the viscosity/log P value of alcohols and droplet size.Ostwald ripening was the dominant breakdown process of nanoemulsions obtained in the ethyl oleate/ Cremophor EL-butanol (3 : 2)/water system. Ostwald ripening rate was increased with increasing surfactant concentration. Dilution (100Â) of this system considerably improved their stability against droplet growth. This study demonstrated that alcohol addition might be a useful tool for preparing Cremophor EL-stabilized nanoemulsions for pharmaceutical applications.

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Section: Stabilitymentioning

confidence: 91%

“…7 Because of the characteristic size of nano-emulsions, coalescence and Ostwald ripening are the main breakdown processes. [7][8][9] Ostwald ripening arises from the difference in chemical potential between small and large droplets, 10 whereas coalescence results from droplet collisions.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of promising Cremophor EL-stabilized o/w nanoemulsions containing short-chain alcohols as a cosurfactant

2017

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“…The acidified nanoparticle emulsions were affected, possibly due to the deterioration of fatty acids and other organic substances in the oil as no preservatives were added. A greater viscosity following storage is possible in nano-particle emulsions produced by non-ionic surfactant systems (Nazarzadeh et al, 2013). The twophase area is supposed to be shrunk with a short chain alcohol that is used as a co-surfactant (Garti et al, 2001) and plays a role in the viscosity accordingly, although this was only slightly observed in this system.…”

Section: Stability Of Tea Seed Oil Nano-particle Emulsionsmentioning

confidence: 96%

Preparation of stable tea seed oil nano-particle emulsions by a low energy method with non-ionic surfactants

Kanlayavattanakul

Lourith

2017

Grasas y Aceites

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SUMMARY:Tea seed oil nano-particle emulsions were prepared. Non-ionic surfactants containing Tween 80 and Span 80 (1:1, w/w) were mixed with propanol (3-9:1, w/w) to give S mix , which was thereafter mixed with tea seed oil. The mixture was titrated with water at 150 rpm to give clear or bluish and bluish-white emulsions. Twelve nano-particle emulsions with 64.64 to 72.73% S mix , 16.66 to 27.27% oil and 9.09 to 16.67% water with particle sizes between 207.00 to 430.10 nm, PDI of 0 to 0.4, z-potential of -42.00 to -49.63 mV, pH of 7.04 to 7.32 and 151.33 to 241.93 cps, were stable following an accelerated stability test and long term storage at room temperature and 4 and 45 ºC for 90 days, although one system (16.66% oil and 66.67% S mix ) was separated. This nano-particle emulsion formulation is concise and feasible for an industrial development of topical products containing tea seed oil.KEYWORDS: Camellia oleifera; Emulsion; Formulation; Self-emulsifying; Stability; Tea seed oil RESUMEN: Preparación de emulsiones estables de nanopartículas de aceite de semilla de té mediante un método de baja energía con tensioactivos no iónicos. Se prepararon emulsiones de nanopartículas de aceite de semilla de té. Se mezclaron tensioactivos no iónicos que contenían Tween 80 y Span 80 (1:1, p/p) con propanol (3-9: 1, p/p) para dar S mix que después se mezcló con aceite de semilla de té. La mezcla se valoró con agua a 150 rpm para dar emulsiones claras o azuladas y blanco azulado. Doce emulsiones de nanopartículas con 64,64 a 72,73% de S mix , 16,66 a 27,27% de aceite y 9,09 a 16,67% de agua con tamaños de partícula entre 207,00 y 430,10 nm, PDI de 0 a 0,4, potencial z de -42,00 a -49,63 mV, PH de 7,04 a 7,32 y 151,33 a 241,93 cps, se mantuvieron estables tras el ensayo de estabilidad acelerada y almacenamiento a largo plazo a temperatura ambiente y 4 y 45 ºC durante 90 días, aunque uno de los sistemas (16,66% de aceite y 66,67% de S mix ) se desvió. Esta formulación de emulsión de nanopartículas es concisa y factible para un desarrollo industrial de productos tópicos que contienen aceite de semilla de té. Citation/Cómo citar este artículo: Kanlayavattanakul M, Lourith N. 2017. Preparation of stable tea seed oil nanoparticle emulsions by a low energy method with non-ionic surfactants. Grasas Aceites 68 (2), e196. http://dx.doi.

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“…12,13 Oil-in-water nanoemulsion is a promising delivery system for the safe and effective delivery of oral insoluble drugs with the potential for application to human therapy by increasing the efficiency of oral administration. 13,14 The drug can be incorporated into the oil droplets with high drug loading, enhancing its oral bioavailability and stability; meanwhile, the increased surface-to-volume ratio of nanoemulsions facilitates drug transport across the cell membrane, achieving sustained and targeted drug delivery. 15 Moreover, the nanoemulsions are easy to prepare and scale up, having great promise for being industrialized and applied in the clinic.…”

Section: Sun Et Almentioning

confidence: 99%

Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions

Sun

Wei²,

Xue³

et al. 2014

IJN

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Background Acetylpuerarin (AP), because of its lower water solubility, shows poor absorption that hinders its therapeutic application. Thus, the aim of this study was to prepare nanoemulsions for AP, enhance its oral bioavailability, and thus improve the therapeutic effect. Methods The nanoemulsions stabilized by D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) were prepared by high-pressure homogenization and characterized in terms of particle size, drug loading, morphology, and in vitro drug release. A lipid digestion model was used to predict in vivo drug solubilization in the gastrointestinal environment. The pharmacokinetics of AP formulations were performed in rats; meanwhile, a chylomicron flow-blocking rat model was used to evaluate the lymphatic drug transport. Moreover, the therapeutic effects of AP nanoemulsions on the model of focal cerebral ischemia-reperfusion for brain injury were also assessed. Results The nanoemulsions with a droplet size of 150 nm were well stabilized by TPGS and showed a high loading capacity for AP. In the digestion model, the distribution of AP in aqueous phase/pellet phase was about 90%/10% for nanoemulsions and 5%/95% for oil solution, indicating that the drug encapsulated in nanoemulsions would present in solubilized form after transportation into the gastrointestinal tract, whereas drug precipitation would occur as the oil solution was orally administered. The area under the curve value of AP nanoemulsions was 5.76±0.56 μg·hour·mL −1 , or was about 2.6 and 1.7 times as great as that of suspension and oil solution, respectively, indicating enhanced drug absorption and thus achieving a better neuroprotection effect on cerebral ischemic reperfusion injury. The values of peak plasma concentration and area under the curve from the blocking model were significantly less than those of the control model, suggesting that the lymphatic transport performed a very important role in absorption enhancement. Conclusion Enhanced oral bioavailability in nanoemulsions was achieved via the mechanism of the maintenance of drug solubilization in the gastrointestinal tract and the enhancement of lymphatic transport, which resulted in therapeutic improvement of cerebral ischemic reperfusion injury.

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On the growth mechanisms of nanoemulsions

Cited by 117 publications

References 42 publications

Development and characterization of promising Cremophor EL-stabilized o/w nanoemulsions containing short-chain alcohols as a cosurfactant

Development and characterization of promising Cremophor EL-stabilized o/w nanoemulsions containing short-chain alcohols as a cosurfactant

Preparation of stable tea seed oil nano-particle emulsions by a low energy method with non-ionic surfactants

Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions

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On the growth mechanisms of nanoemulsions

Cited by 117 publications

References 42 publications

Development and characterization of promising Cremophor EL-stabilized o/w nanoemulsions containing short-chain alcohols as a cosurfactant

Development and characterization of promising Cremophor EL-stabilized o/w nanoemulsions containing short-chain alcohols as a cosurfactant

Preparation of stable tea seed oil nano-particle emulsions by a low energy method with non-ionic surfactants

Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-&alpha;-tocopheryl polyethylene glycol 1000 succinate nanoemulsions

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Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions