A numerical study was performed to investigate the thermal performance characteristics of an enhanced tube heat exchanger fitted with punched delta-winglet vortex generators. Computational fluid dynamics modeling was applied using the k–ε renormalized group turbulence model. Benchmarking was performed using the results of the experimental study for a similar geometry. Attack angles of 30°, 50°, and 70° were used to investigate the heat transfer and pressure drop characteristics of the enhanced tube. Flow conditions were considered in the turbulent region in the Reynolds number range of 9100 to 17,400. A smooth tube was employed for evaluating the increment in the Nusselt number and the friction factor characteristics of the enhanced tube. The results show that the Nusselt number, friction factor, and thermal performance factor have a similar tendency. The presence of this insert offers a higher thermal performance factor as compared to that obtained with a plain tube. Vortex development in the flow structure aids in generating a vortex flow, which increases convective heat transfer. In addition, as the angle is varied, it is observed that the largest attack angle provides the highest thermal performance factor. The greatest increase in the Nusselt number and friction factor, respectively, was found to be approximately 3.7 and 10 times greater than those of a smooth tube. Through numerical simulations with the present simulation condition, it is revealed that the thermal performance factor approaches the value of 1.1. Moreover, the numerical and experimental values agree well although they tend to be different at high Reynolds number conditions. The numerical and experimental values both show similar trends in the Nusselt number, friction factor, and thermal performance factor.