On the Histamine Receptor of the Canine Myocardium and Coronary Vasculature

Takeda, Kazuki; Katano, Yumi; Nakagawa, Yoshito; Tsukada, Tokumasa; Hashimoto, Takehisa; Nakazawa, Makoto; Hashimoto, Keitaro; Otorii, Takeshi; Imai, Shoichi

doi:10.1254/jjp.28.545

Cited by 10 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The response of coronary hemodynamics to Hi-receptor activation in man, at the histamine concentration used in our study, was characterized by a significant decrease in CVR in the majority of patients. Since there was no net change in the determinants of MVO2, this decrease in CVR could to some extent be attributed to the stimulation of vasodilating Hx-receptors present in the small resistance coronary arteries, in agreement with reports of H 1-receptor-induced vasodilatation without changes in MVO 2 [9,10]. We cannot exclude, however, that other mediators released by histamine may be responsible for this effect.…”

Section: Discussionsupporting

confidence: 90%

Effects of histamine H1-receptor stimulation on coronary hemodynamics in man

et al. 1985

View full text Add to dashboard Cite

Exogenous histamine in man induces significant cardiovascular effects mediated by activation of H1 and H2-receptors present on human heart and on coronary arteries. We studied the effects of selective H1-receptor stimulation on human coronary hemodynamics in 10 patients undergoing cardiac catheterization. All patients were pretreated with cimetidine before the histamine infusion (0.5 micrograms/kg/min i.v. for 5 min). Six of these patients had normal coronary arteries and four had single vessel coronary artery disease (CAD) and vasospastic angina. During the study heart rate was held constant (100 beats/min) by coronary sinus pacing. We measured mean aortic pressure (MAP), coronary sinus blood flow (CSBF), coronary vascular resistance (CVR) and myocardial oxygen consumption (MVO2) at rest, during histamine infusion, and 10 min after the end of the infusion. During infusion, MAP decreased from 103 +/- 5 to 85 +/- 6 mmHg (p less than 0.02) and CVR from 1.00 +/- 0.16 to 0.81 +/- 0.14 mmHg/ml/min (p less than 0.05); CSBF and MVO2 did not significantly change. All parameters returned to baseline at the end of the infusion. The response was similar in patients with normal coronary arteries and in 3 patients with CAD. Only one patient with CAD developed angina with ST segment elevation in D3, reduction in CSBF and an increase in CVR. These results indicate that H1-receptor stimulation in man induces significant coronary dilatation and that histamine infusion after cimetidine pretreatment is unlikely to provoke coronary spasm in patients with vasospastic angina.

show abstract

Section: Discussionsupporting

confidence: 90%

Effects of histamine H1-receptor stimulation on coronary hemodynamics in man

et al. 1985

View full text Add to dashboard Cite

show abstract

“…In relatively simple and controlled systems such as the blood-perfused right atrium [9] or the heart-lung preparation [8,10], histamine was found to produce positive inotropic responses, either partially or totally blocked by H 1 or a combination of H1 and H2 antagonists. However, it should be noted that in all cases the amine produced simultaneous positive chronotropic effects and that, in general, susceptibility to blockade by the antagonists tested was similar for inotropic and chronotropic responses.…”

Section: Discussionmentioning

confidence: 99%

“…Although such responses were not systematically evaluated in the present study, preliminary experiments in unpaced preparations showed that the threshold inotropic dose of 0.1 mg already produced a substantial increase in heart rate. By the same token, histamine elicits coronary dilatation in the dog, presumably through stimulation of H 1 and H 2 receptors [10,14,23]. Evaluation of this effect was not attempted, both because it has already been adequately characterized and in order not to complicate more an already complex experimental preparation.…”

Section: Effect8 Of Hi8tamine On 180volumic Pressure Before and Aftermentioning

confidence: 99%

Effects of histamine on atrial and ventricular contractility in the canine isovolumic heart

Vidrio

1990

Agents and Actions

View full text Add to dashboard Cite

The effects of intracoronary administration of histamine on atrial and ventricular contractility were determined in a paced canine isovolumic heart preparation. Contractility was assessed by recording the pressure developed in saline-filled balloons placed in each of the four cardiac chambers. At doses above 0.1 mg and up to 100 mg histamine produced dose-related positive inotropic responses in all chambers. These were preceded by transient negative effects. The positive responses were not affected by a combination of H1 and H2 receptor antagonists antazoline and cimetidine but were almost completely abolished by the beta adrenoceptor blocker timolol. The negative responses were uninfluenced by either treatment. It was concluded that, in the canine isovolumic heart not subjected to complicating chronotropic and extracardiac factors, moderate doses of histamine are devoid of inotropic effects. Higher doses do produce myocardial stimulation, not mediated by histamine receptors, but probably due to norepinephrine release. These responses are preceded by transient non-specific depressant effects.

show abstract

Inhibition of Histamine‐Stimulated Increases in Neart Rate in Man with the H₂‐Histamine Receptor Antagonist Cimetidine

Grund

Hunninghake

1981

The Journal of Clinical Pharma

View full text Add to dashboard Cite

The influence of an H2‐histamine receptor antagonist, cimetidine, on histamine‐induced changes in heart rate and blood pressure was examined in a randomized double‐blind study in six fasted male subjects. The intravenous infusion of histamine (10 μg/min) for 20 minutes caused an immediate and sustained increase in heart rate (26 per cent and a transient fall in mean arterial blood pressure (10 per cent). Cimetidine pretreatment (300 mg intravenously) inhibited histamine‐elevated heart rate by 75 per cent (P < 0.05) and histamine‐decreased blood pressure by 54 per cent (P < 0.05). Cimetidine by itself did not cause significant changes in heart rate or blood pressure. These results illustrate that H2‐histamine receptor antagonists significantly inhibit histamine‐induced increases in heart rate in man and support the potential use of cimetidine in certain cases of tachyarrhythmia.

show abstract

On the Histamine Receptor of the Canine Myocardium and Coronary Vasculature

Abstract: Abstract-To indentify the histamine-receptors in the canine myocardium, experiments were performed in the canine heart-lung preparation supported by a donor.

Cited by 10 publications

References 14 publications

Effects of histamine H1-receptor stimulation on coronary hemodynamics in man

Effects of histamine H1-receptor stimulation on coronary hemodynamics in man

Effects of histamine on atrial and ventricular contractility in the canine isovolumic heart

Inhibition of Histamine‐Stimulated Increases in Neart Rate in Man with the H₂‐Histamine Receptor Antagonist Cimetidine

Contact Info

Product

Resources

About

On the Histamine Receptor of the Canine Myocardium and Coronary Vasculature

Abstract: Abstract-To indentify the histamine-receptors in the canine myocardium, experiments were performed in the canine heart-lung preparation supported by a donor.

Cited by 10 publications

References 14 publications

Effects of histamine H1-receptor stimulation on coronary hemodynamics in man

Effects of histamine H1-receptor stimulation on coronary hemodynamics in man

Effects of histamine on atrial and ventricular contractility in the canine isovolumic heart

Inhibition of Histamine‐Stimulated Increases in Neart Rate in Man with the H2‐Histamine Receptor Antagonist Cimetidine

Contact Info

Product

Resources

About

Inhibition of Histamine‐Stimulated Increases in Neart Rate in Man with the H₂‐Histamine Receptor Antagonist Cimetidine