On the history of the study of haemorrhagic fever with renal syndrome in eastern Russia

Сиротин, Б. З.; Keiser, Natalia Petrovna

doi:10.1093/ndt/16.6.1288

Cited by 14 publications

(7 citation statements)

References 1 publication

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“…If – even in the absence of the necessary diagnostic tools – hantavirus epidemics had taken place before the first reliably recorded outbreak of 1995–1996 (Heyman et al, 1999) they would not have gone unnoticed given the sometimes severe clinical course of hantavirus disease, i.e., acute renal failure (ARF) and/or acute respiratory distress syndrome (ARDS). In Russia for instance, hantavirus infections were already diagnosed based on clinical features as early as 1935 (Sirotin and Keiser, 2001). …”

Section: The Hantavirus Situation In Belgiummentioning

confidence: 99%

In Search for Factors that Drive Hantavirus Epidemics

Heyman¹,

Thoma²,

Marié³

et al. 2012

Front. Physio.

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In Europe, hantaviruses (Bunyaviridae) are small mammal-associated zoonotic and emerging pathogens that can cause hemorrhagic fever with renal syndrome (HFRS). Puumala virus, the main etiological agent carried by the bank vole Myodes glareolus is responsible for a mild form of HFRS while Dobrava virus induces less frequent but more severe cases of HFRS. Since 2000 in Europe, more than 3000 cases of HFRS have been recorded, in average, each year, which is nearly double compared to the previous decade. In addition to this upside long-term trend, significant oscillations occur. Epidemic years appear, usually every 2–4 years, with an increased incidence, generally in localized hot spots. Moreover, the virus has been identified in new areas in the recent years. A great number of surveys have been carried out in order to assess the prevalence of the infection in the reservoir host and to identify links with different biotic and abiotic factors. The factors that drive the infections are related to the density and diversity of bank vole populations, prevalence of infection in the reservoir host, viral excretion in the environment, survival of the virus outside its host, and human behavior, which affect the main transmission virus route through inhalation of infected rodent excreta. At the scale of a rodent population, the prevalence of the infection increases with the age of the individuals but also other parameters, such as sex and genetic variability, interfere. The contamination of the environment may be correlated to the number of newly infected rodents, which heavily excrete the virus. The interactions between these different parameters add to the complexity of the situation and explain the absence of reliable tools to predict epidemics. In this review, the factors that drive the epidemics of hantaviruses in Middle Europe are discussed through a panorama of the epidemiological situation in Belgium, France, and Germany.

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Section: The Hantavirus Situation In Belgiummentioning

confidence: 99%

In Search for Factors that Drive Hantavirus Epidemics

Heyman¹,

Thoma²,

Marié³

et al. 2012

Front. Physio.

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“…[2][3][4] Although renal involvement is a distinctive feature of HFRS, extrarenal manifestations, including acute impairment of visual function, acute myopia, central nervous system (CNS) complications with seizures, myocarditis, and severe gastrointestinal hemorrhages, are infrequently reported in case reports and in some cases, are fatal. [5][6][7] Furthermore, unfamiliarity with these clinical presentations among clinicians can cause diagnostic problems and result in unnecessary procedures.…”

mentioning

confidence: 99%

Experience with Extrarenal Manifestations of Hemorrhagic Fever with Renal Syndrome in a Tertiary Care Hospital in South Korea

Park¹,

Kang²,

Kang³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Reports on the clinical entity of hemorrhagic fever with renal syndrome (HFRS) have focused on acute renal failure. Data on the extrarenal manifestations are limited primarily to case reports. In this study, protean extrarenal manifestations involving the major organs occurred in one-third of patients with HFRS during various stages (i.e., febrile phase through diuretic phase). Pancreatobiliary manifestations and major bleeding occurred in 11% and 10% of patients, respectively. Cardiovascular and central nervous system manifestations developed during the febrile or oliguric phase, whereas pancreatobiliary manifestations and major bleeding were detected even in the diuretic phase. Thus, close monitoring of and additional knowledge about various extrarenal manifestations are needed.

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“…HPS is noted for influenza-like symptoms including high fever, headache, myalgia and shortness of breath [45]. Hypotension and acute non-cardiac pulmonary oedema may develop within 2-15 days.…”

Section: Hantavirus-associated Major Clinical Syndromesmentioning

confidence: 99%

Effects of Anthropogenic Events and Viral Persistence on Rodent Reservoirs of Hantavirus Infection: Understanding Host-Pathogen Interactions Facilitates Novel Approaches to Intervention Strategies

Mahmud-Al-Rafat¹,

E-Sobhani²,

Taylor‐Robinson³

2015

AJIDM

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Hantaviruses are primarily rodent-borne pathogens which have received considerable attention recently due to their high mortality rates in humans. In order to find the causes of rapid transmission and emergence of hantavirus-associated diseases anthropogenic changes are a priority. These include deforestation, urbanization, noise pollution, light pollution and electromagnetic fields, all of which have been shown to profoundly affect rodent physiology and immunology. Moreover, anthropogenic events promote human-rodent co-habitation and thereby provide a driver to increase rates of transmission and, by extrapolation, levels of infection in humans. Such environmental disruption acts as a chronic stressor to rodents and causes elevated concentrations of glucocorticoids, which are a major class of immunosuppressive hormone. Glucocorticoids are responsible for altering the immune tolerance of rodents, thereby rendering them susceptible to infection. Glucocorticoids induce regulatory T lymphocytes to reduce inflammatory and antiviral responses and to activate regulatory responses, principally through production of the cytokines interleukin-10 and transforming growth factor-β to support viral persistence. In order to develop a low-cost intervention strategy for hantavirus infection consideration should be given to a systemic approach to therapy. This would both aim to achieve a reduction of anthropogenic stressors and to gain a greater understanding of host-pathogen interactions.

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On the history of the study of haemorrhagic fever with renal syndrome in eastern Russia

Cited by 14 publications

References 1 publication

In Search for Factors that Drive Hantavirus Epidemics

In Search for Factors that Drive Hantavirus Epidemics

Experience with Extrarenal Manifestations of Hemorrhagic Fever with Renal Syndrome in a Tertiary Care Hospital in South Korea

Effects of Anthropogenic Events and Viral Persistence on Rodent Reservoirs of Hantavirus Infection: Understanding Host-Pathogen Interactions Facilitates Novel Approaches to Intervention Strategies

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