On the I.R. spectra of the isomers of trichlorotriaquoruthenium(III)

Durig, J. R.; McAllister, W. A.; Mercer, E. E.

doi:10.1016/0022-1902(67)80244-6

Cited by 9 publications

(4 citation statements)

References 5 publications

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“…A weak band due to Ru−N is present at 466 cm −1 in the theoretical spectrum, but it is out of the range for the experimental one. The same applies to the Ru−Cl vibrations (280 cm −1 ), according to the literature data [36] . These vibrations are essential to distinguish between the terminal and bridging Cl ligands [31] …”

Section: Resultsmentioning

confidence: 93%

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Ru(II)‐Nitrophenylhydrazine/Chlorophenylhydrazine Complexes: Nanoarchitectonics, Biological Evaluation and In silico Study

Eichhorn,

Đošić,

Dimić

et al. 2024

Eur J Inorg Chem

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Ru(II)‐arene compounds are being investigated as anticancer agents due to the biocompatibility of ruthenium and their structural diversity. Two newly synthesized Ru(II) complexes, [RuCl(η6‐p‐cymene)(3‐DNPH)] chlorido(η6‐p‐cymene)(k²‐N,N'‐3‐nitrophenylhydrazine) (1) and [RuCl(η6‐p‐cymene)(3‐CNPH)] chlorido(k²‐N,N'‐3‐chlorophenylhydrazine)(η6‐p‐cymene) (2), are experimentally (IR, NMR) and theoretically (B3LYP/6‐31+G(d,p)(H,C,N,Cl)/LanL2DZ(Ru)) characterized. Experimental and theoretical values of 1H and 13C chemical shifts and position of the most intense vibrational bands showed high correlation coefficients and low mean absolute errors, proving the predicted structure and applicability of the selected level of theory. Cell viability studies performed on MDA‐MB‐468, BT‐474, and PC3 cells using MTT and CV assay indicated the activity of the second complex similar to the activity of cisplatin towards BT‐474 breast cancer cells. The spectrofluorimetric measurements of Bovine Serum Albumin showed the binding process's spontaneity of complexes and protein, with a binding energy of around ‐30 kJ mol‐1. Detailed molecular docking analysis allowed the elucidation of the binding mechanism through specific intermolecular interactions. Both compounds showed a higher affinity towards BSA than naproxen and cisplatin. Molecular docking simulations proved the spontaneity of the complexes binding to DNA. Based on these promising results, further biological examinations of these compounds are advised.

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Section: Resultsmentioning

confidence: 93%

“…The same applies to the RuÀ Cl vibrations (280 cm À 1 ), according to the literature data. [36] These vibrations are essential to distinguish between the terminal and bridging Cl ligands. [31]…”

Section: Ir Spectroscopy (Experimental and Theoretical)mentioning

confidence: 99%

Ru(II)‐Nitrophenylhydrazine/Chlorophenylhydrazine Complexes: Nanoarchitectonics, Biological Evaluation and In silico Study

Eichhorn,

Đošić,

Dimić

et al. 2024

Eur J Inorg Chem

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“…A follow-up work will thus include the encapsulation of this complex into different carriers such as liposomes or solid lipid nanoparticles, the evaluation of its uptake by different cell types and unicellular microorganisms, and the study of its potential application as a cytotoxic or biocide agent. [43]; the Ru-O band is attributed with base on the references [44] and [45].…”

Section: Discussionmentioning

confidence: 98%

“…A combination of stretching and bending modes account for the most intense spectral band, observed at 1510 cm -1 in pure curcumin [43] and at 1508 and 1505 cm -1 in complex 1. Also noteworthy is the observation of a new band at 482 cm -1 in the spectrum of complex 1, attributed to the Ru-O stretch [44,45].…”

Section: Fourrier-transform Infrared Spectroscopy In the Solid-statementioning

confidence: 97%

A ruthenium(II)-trithiacyclononane curcuminate complex: Synthesis, characterization, DNA-interaction, and cytotoxic activity

Henriques

Faustino

Silva

et al. 2017

Journal of Coordination Chemistry

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A ruthenium(II) trithiacyclononane curcuminate complex: synthesis, characterisation, DNA interaction and cytotoxic activityThe coordination of inorganic ruthenium(II) complexes to anionic oxygen-based donors is very rare. In this study, the simple, one-pot preparation of [ruthenium(II)(trithiacyclononane)(curcumin)(S-DMSO)]Cl (1) and its structural characterisation by elemental analysis, FT-IR, 1-D and 2-D NMR, ESI + -MS as well as UV-VIS and fluorescence are described. DNA thermal degradation studies showed that the complex 1 has DNA-intercalating ability, while pure curcumin is a non-intercalative compound. The in vitro cytotoxic activity of the complex 1, in comparison with that of pure curcumin, was investigated using the tumor human prostate cell line, PC-3, and the pre-neoplastic cell line, PNT-2.Results showed that complex 1 is innocuous towards normal prostate epithelial cells and, whereas curcumin is toxic in concentrations of 50 and 80 µM. On the tumour cell line PC-3, the complex 1 did not cause viability changes whereas curcumin exhibited dose-dependent inhibition. This study suggests that coordination with the trithiacyclononane ruthenium(II) scaffold stabilises the photochemical properties and biologic activity of curcumin.

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1984

The Chemistry of Ruthenium

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On the I.R. spectra of the isomers of trichlorotriaquoruthenium(III)

Cited by 9 publications

References 5 publications

Ru(II)‐Nitrophenylhydrazine/Chlorophenylhydrazine Complexes: Nanoarchitectonics, Biological Evaluation and In silico Study

Ru(II)‐Nitrophenylhydrazine/Chlorophenylhydrazine Complexes: Nanoarchitectonics, Biological Evaluation and In silico Study

A ruthenium(II)-trithiacyclononane curcuminate complex: Synthesis, characterization, DNA-interaction, and cytotoxic activity

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