On the identification and frequency of the J and K cholinesterase phenotypes in a Caucasian population.

Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease

“…29 Variation in the BuChE gene (BCHE) can lead to reduced activity of the enzyme. 30 The most common reported polymorphism is the K variant (BCHE-K). 31 Homozygous individuals have approximately 30% reduced plasma BuChE activity 31 and show a slower rate of cognitive decline.…”

Recognition of Two New Phenotypes Segregating the E₁^k Allele for Plasma Cholinesterase

“…pH 7.4) at 25°C [Whittaker, 1977). The RO2-0683 [dimethylcarbamate of (2-hydroxy-5-phenyl benzyl) trimethylammonium bromide) inhibition numbers were assayed at 25°C in duplicate using 5x 10 ' M benzoylcholine as substrate and I0'8 M RO2-0683 as differential in hibitor [Liddell et al, 1963;Evans and Wardell, 1984).…”

Anesthesiology, the birth of pharmacogenetics and Werner Kalow

“…2,3 Depuis, beaucoup de nouvelles méthodes biochimiques de classification de l'activité de la cholinestérase plasmatique et des phénotypes ont été mises au point. [4][5][6][7][8] Néanmoins, la méthode du pourcentage d'inhibition à la dibucaïne de Kalow demeure la référence pour la classification des phénotypes. À n'en pas douter, la méthode de Kalow a résisté au temps, ce qui est plus qu'on ne peut en dire de la plupart des tests diagnostiques élaborés dans les années 1950.…”

“…2,3 In the intervening years many new biochemical methods for classifying plasma cholinesterase activity and phenotypes have been introduced. [4][5][6][7][8] Nonetheless, Kalow's dibucaine inhibition percentage method remains the 'gold standard' for the classification of phenotypes. Kalow's method has undoubtedly stood the test of time, which is more than can be said for most diagnostic tests developed in the 1950s.…”