Laboratory experiments have shown that wettability affects fluid distribution at the pore scale and therefore has an important effect on the end-point saturations and the shapes of capillary pressure (Pc) and relative permeability (kr) curves. At reservoir scale, the combined effect of wettability and permeability heterogeneity is not so clear. Effects due to a change in the end-point saturations is straightforward but the ones due to the change of the shape of the Pc curve has not been studied. In reservoir simulation, the Kr curves are generally known but there is an uncertainty on the Pc curves, due to the lack of information on wettability (imbibition curves are derived from mercury porosimetry or drainage curves). The purpose of the paper is to quantify the effect of this uncertainty on oil recovery. Breakthrough times and fraction of recoverable oil during waterflood were numerically studied on a simple 2-dimensional reservoir using 3 and 5 facies. Permeability heterogeneity is characterized by its stochastic properties (variance and correlation length). In order to obtain a uniform reservoir wettability, the Pc curves of the various facies are calculated using the classical J function. The results are presented as recovery vs. correlation lengths, CL and wettability indices, WI. At intermediate flow rate ( 0.3 m/day ),• from intermediate to water-wet wettabilities (0 < WI < 1)), final (asymptotic) recovery is always near 1, recovery decreasing with an increase of the WI. The correlation length. shows no significant effect.• for oil-wet reservoirs, final recovery is about 30% less. In addition, there is a strong effect of heterogeneity : the best recovery occurs for layered reservoirs.At higher flow rates, capillary effects are comparatively reduced and the effect of wettability on recovery becomes less important.2