Abstract. Let C be an algebraic curve defined over a number field K, of positive genus and without K-rational points. We conjecture that there exists some extension field L over which C has points everywhere locally but not globally. We show that our conjecture holds for all but finitely many Shimura curves of the form, where D > 1 and N are coprime squarefree positive integers. The proof uses a variation on a theorem of Frey, a gonality bound of Abramovich, and an analysis of local points of small degree.