Hydrodynamic journal bearings, coated with polytetrafluoroethylene (PTFE) and lubricated by water, have been widely used in ships and large-scale pumps, and the function is to maintain the stability of rotor system. However, slip velocity exists on the PTFE-coated surface, whose effect is still an open question. This study aims to investigate the static characteristics of water-lubricated hydrodynamic journal bearings under three-dimensional slip velocity boundary conditions. Firstly, under the non-slip boundary condition, the CFD (computational fluid dynamics) method with ANSYS Fluent is verified based on the Reynolds lubrication equation and the open literature. Then, a three-dimensional slip velocity equation that is based on the Navier slip velocity boundary condition is proposed and embedded into Fluent. Finally, the effects of slip length on the static characteristics are analyzed. Under the same eccentricity ratio, with the increase in slip length, the load capacity decreases due to the decrease of the pressure circumferential gradient, and the friction power decreases. Under the same eccentricity ratio and the same slip length, with the increase in the attitude angle, the load capacity and friction power increase. However, under the non-slip boundary condition, the effects of attitude angle on the load capacity and friction power are insignificant. This paper could provide a reference for studying slip velocity in the hydrodynamic journal bearing.