On the Inhibitory Effect of C17-Sulfoconjugated Catechol Estrogens upon Lipid Peroxidation of Rat Liver Microsomes.

Takanashi, Kaori; Watanabe, Kimitsuna; Yoshizawa, Itsuo

doi:10.1248/bpb.18.1120

Cited by 22 publications

(10 citation statements)

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“…Antioxidants that inhibit lipid peroxidation sometimes do not scavenge DPPH. For example, the strong antioxidants butylated hydroxytoluene (Mellors & Tappel 1966) and oestradiol (Takanashi et al 1995) do not efficiently scavenge DPPH. The strong antioxidant activity of butylated hydroxytoluene probably can not be explained only by the scavenging ability of free radicals (Lambert et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Antioxidative and Prooxidative Action of Stilbene Derivatives

Miura¹,

Muraoka

Ikeda

et al. 2000

Pharmacology & Toxicology

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The effects of stilbene derivatives, including resveratrol, diethylstilboestrol and stilbene, as antioxidants or prooxidants were examined. Resveratrol and diethylstilboestrol, but not stilbene, strongly inhibited NADPH-and adenosine 5ø-diphosphate (ADP)-Fe 3π -dependent lipid peroxidation at the initial and propagation stages. In addition, phenolic stilbenes also inhibited ultraviolet light-induced lipid peroxidation. Resveratrol and diethylstilboestrol efficiently scavenged 2,2ø-azobis-(2-amidinopropane)-dihydrochloride peroxyl radicals. However, 2,2ø-diphenyl-p-picrylhydrazyl radicals were trapped only by resveratrol, but not by diethylstilboestrol. These results suggest that the inhibitory effect of phenolic stilbenes on lipid peroxidation was due to their scavenging ability of lipid peroxyl and/or carbon-cantered radicals. Resveratrol efficiently reduced ADP-Fe . The strand breaks of DNA were stimulated during the interaction of resveratrol with ADP-Fe 3π in the presence of H 2 O 2 . These results suggest that phenolic stilbenes act as antioxidants of membrane lipids and that resveratrol has a prooxidative effect DNA damage during interaction with ADP-Fe 3π in the presence of H 2 O 2 .

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Section: Discussionmentioning

confidence: 99%

Antioxidative and Prooxidative Action of Stilbene Derivatives

Miura¹,

Muraoka

Ikeda

et al. 2000

Pharmacology & Toxicology

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“…Some catechol steroids were reported to have effective antioxidant properties in lipoproteins 171 and rat liver microsomes 172 . The hormonal catecholamines are of particular interest.…”

Section: Dihydroxy Phenols: Catechols and 14-hydroquinones-intramolementioning

confidence: 99%

Phenols as Antioxidants

Ross

Barclay

Vinqvist

2009

Patai's Chemistry of Functional Groups

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“…Moreover, estradiol has been shown to scavenge free radicals and decrease the oxidation of LDL. 24 Another potential role for estradiol to influence LDL oxidation is its affect on NO. Estradiol has been shown to induce the production of NO.…”

Section: Group؋sex Analysismentioning

confidence: 99%

Exercise and Cardiovascular Disease

Shern-Brewer

Santanam

Wetzstein

et al. 1998

ATVB

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Abstract-The oxidation of low density lipoprotein (LDL) has been suggested as a key event in atherogenesis. Paradoxically, exercise, which imposes an oxidative stress, is an important deterrent of cardiovascular disease. In study 1 the oxidizability of LDL was enhanced in exercisers compared with sedentary controls. The lag time of isolated LDL subjected to copper-induced in vitro oxidation was significantly shortened in the exercisers compared with sedentary subjects. This increased sensitivity was not due to a decreased presence of vitamin E. Instead, these findings suggested that the LDL of exercisers may contain increased amounts of preformed lipid peroxides, which account for the increased oxidizability. In study 2, a groupϫsex ANOVA revealed that male exercisers had a significantly longer mean lag time than male sedentary subjects and that females had similar mean lag times regardless of exercise group. This remained the case when statistical adjustment was made for age, body mass index, blood lipid levels, LDL, and plasma ␣-tocopherol levels. Study 1 exercisers had been in training for a shorter time (Ͻ1 year) than study 2 exercisers (Ͼ2 years). These findings suggest that truly "chronic" exercise (aerobic intensity over several months) decreases the susceptibility of a male exerciser's LDL to undergo oxidation. Conversely, regular aerobic stress during an overall shorter time span creates a more oxidative environment in the body, thus increasing the susceptibility of LDL to undergo oxidation. The oxidative stress of aerobic exercise does not appear to adversely affect the oxidizability of LDL in women.

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On the Inhibitory Effect of C17-Sulfoconjugated Catechol Estrogens upon Lipid Peroxidation of Rat Liver Microsomes.

Cited by 22 publications

References 0 publications

Antioxidative and Prooxidative Action of Stilbene Derivatives

Antioxidative and Prooxidative Action of Stilbene Derivatives

Phenols as Antioxidants

Exercise and Cardiovascular Disease

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