On the Inhibitory Effects of Somatostatin on Arginine-Induced Insulin and Growth Hormone Secretion in Man: Influence of Aminophylline

Caviezel, F; Albertini, A; Spotti, D.; Pozza, G.

doi:10.1055/s-2007-1018626

Cited by 1 publication

(2 citation statements)

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“…Our data are in contrast with the findings of Ligumsky et al (1983) of an increased PG E2 secretion as a cause of SRIF-dependent inhibition of gastric acid secretion in the rat stomach. Caviezel et al (1983) demonstrated with a protocol similar to ours by using an infusion of theophylline in the place of LAS, that the effect of SRIF is also not dependent upon variations of endocellular cAMP levels. Gerich et al (1973) reached the same cOnclusions in a more complex study.…”

Section: Resultssupporting

confidence: 59%

See 1 more Smart Citation

The Effect of Lysine Acetylsalicylate on Somatostatin Inhibition of Insulin Secretion Induced by Arginine

Altomonte¹,

Zoli²,

Accili³

et al. 2009

Exp Clin Endocrinol Diabetes

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The inhibitory effect of somatostatin (SRIF) on immunoreactive insulin release and on many other hormonal secretions has been widely studied in both animal and man. However, the mechanism by which SRIF acts on these functions remains poorly defined. Aim of this study is to determine the inhibitory effect of SRIF on insulin secretion induced by arginine after the administration of lysine acetylsalicylate (LAS) in a dose which inhibits the endogenous synthesis of prostaglandins. Ten healthy informed volunteer subjects were studied. Four studies were carried out in randomized order, each one separated by a three day interval. The first study was a test of arginine (25 g i.v. in 30 min). The second study was a test of arginine with SRIF infusion (150 micrograms bolus followed by 100 micrograms/h for 120 min). The third study was a test of arginine with an infusion of SRIF and LAS (66 mg/min for 120 min). The fourth study was a test of arginine with LAS infusion. Plasma insulin levels were determined by radioimmunoassay. After arginine administration the typical biphasic insulin response was observed with a precocious peak at 3 min and a late peak at 30 min. This response is not significantly modified under LAS infusion. With the infusion of SRIF at a dose of 100 micrograms/hr after arginine administration only a very modest insulin response was observed. The addition of LAS does not modify the inhibitory effect of SRIF on insulin secretion induced by arginine. This result demonstrates that the inhibitory action of SRIF on the secretion of insulin is not dependent upon the activation of the endocellular prostaglandin system.

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Section: Resultssupporting

confidence: 59%

“…However, the mechanism of the SRIF action is still poorly understood (Chen et al, 1974;De Vane et al, 1974;Efendic et al, 1974). Some authors have emphasized the importance of cAMP (Caviezel et al, 1983), while others have emphasized intracellular calcium ions (Curry et al, 1974).…”

Section: Introductionmentioning

confidence: 99%