In the paper, we give an affirmative answer to the conjecture in [2]. We prove that a Shamsuddin derivation D is simple if and only if Aut(K[x, y 1 , . . . , y n ]) D = {id}. In addition, we calculate the isotropy groups of some Shamsuddin derivations of K[x, y 1 , . . . , y r ].