The use of chemical reagents, such as paraffin inhibitors, viscosity regulators, anti-turbulence, and depressant additives, has recently been shown to significantly impact the rheological properties of oil flow. These additives function by forming asphaltene colloids through adsorption on aggregates, thereby reducing the energy of their interactions. This article describes the development, laboratory testing, and potential application in pipeline transport of the ANA-10 complex-action reagent, which combines the effects of an inhibitor of asphaltene-resin-paraffin deposits and an oil viscosity regulator. One component of the developed reagent is a synthetic carboxylic acid ester, while another group of active components includes imides of synthetic fatty acids, used as anti-wear additives for oils. The cold rod method was used to study the ability of the developed reagents to inhibit paraffin precipitation in oil. Rheological properties were analyzed at a low shear rate of 3.75 s–1, corresponding to the starting loads at oil pumping stations, as well as across a range of shear rates and temperatures typical for oil collection, in-field, and main transportation processes. When the newly developed reagent was applied to a specific section of the oil pipeline without additional supply branches, it reduced pressure losses at the pump by an average of 7% and decreased the frequency of pipe cleaning operations by 2.5 times.