Design and manufacture of mechanical elements are strongly influenced by the evaluation of the residual stresses due to their effects on the material strength. This paper presents numerical and experimental results performed on AW 6082-T6 aluminum alloy drilled specimens when the hole is created after a bilateral indentation process. The plastic deformation induced by the indenters creates a compressive residual stress field around the hole, which persists after the drilling operation. Several numerical analysis have been carried out in ANSYS APDL explicit solver for different indentation depths and hole diameters in order to evaluate the compressive circumferential stresses, optimal process parameters and relevant geometric features. Fatigue tests are performed in order to determine the cycles to failure and the corresponding Wöhler diagram