2007
DOI: 10.3748/wjg.v13.i9.1384
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On the mechanical behavior of the human biliary system

Abstract: This paper reviews the progress made in understanding the mechanical behaviour of the biliary system. Gallstones and diseases of the biliary tract affect more than 10% of the adult population. The complications of gallstones, i.e. acute pancreatitis and obstructive jandice, can be lethal, and patients with acalculous gallbladder pain often pose diagnostic difficulties and undergo repeated ultrasound scans and oral cholecystograms. Moreover, surgery to remove the gallbladder in these patients, in an attempt to … Show more

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Cited by 39 publications
(37 citation statements)
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“…Incomplete drainage of the gallbladder may occur when the resistance to flow is too high; this requires further study. Preliminary work by us 29,31 suggests a correlation between pain and mechanical stresses of the biliary system, and this paper indicates that non-Newtonian effects will contribute to these stresses.…”
Section: Discussionmentioning
confidence: 74%
“…Incomplete drainage of the gallbladder may occur when the resistance to flow is too high; this requires further study. Preliminary work by us 29,31 suggests a correlation between pain and mechanical stresses of the biliary system, and this paper indicates that non-Newtonian effects will contribute to these stresses.…”
Section: Discussionmentioning
confidence: 74%
“…The nonlinear modelling itself also still faces the same challenges as the linear model, namely, how to estimate the intraluminal pressure non-invasively, and how to evaluate the effects of patient specific GB geometries. In view of this, it seems plausible to continue to use the linear model as a clinical tool to provide a quick first evaluation of the stress trend, as has been done successfully in the previous studies (Luo et al 2007;Li et al 2011a;Li et al 2011b), but bear in mind that the stress within the GB wall may be underestimated by approximately a factor of approximately 1.6, which reflects the ratio of the wall thickness reduction. However, for clinical cases that require careful attention and involve critical decision making, finite strain nonlinear models must used to provide more accurate stress evaluations.…”
Section: Discussionmentioning
confidence: 99%
“…Considering the biliary tract as a pump-pipe system, the gallbladder provides the driving force with the flow rate of bile further depending on resistance in the duct system and the pressure gradient between the gallbladder and the distal part of the common bile duct [10]. Both supersaturation of the bile with cholesterol or bilirubin and bile stasis as a consequence of gallbladder hypomotility accelerate stone formation.…”
Section: Patients At Risk For the Development Of Gallstonesmentioning
confidence: 99%