On the mechanics of cerebral aneurysms: experimental research and numerical simulation

Parshin, D. V.; Kuyanova, Yu. O.; Yunoshev, A. S.; Ovsyannikov, K. S.; Dubovoy, A. V.

doi:10.1088/1742-6596/894/1/012071

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Aneurysms, pathological dilation of blood vessel and weakening of the vessel wall, affect a significant portion of the adult population [1][2][3]. There exists an extensive literature with a large focus on possible correlations between the occurrence of aneurysms and hydrodynamic factors [4][5][6]. The findings are, however, inconsistent and sometimes conflicting.…”

Section: Introductionmentioning

confidence: 99%

Vertebral artery fusiform aneurysm geometry in predicting rupture risk

et al. 2018

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Cerebral aneurysms affect a significant portion of the adult population worldwide. Despite significant progress, the development of robust techniques to evaluate the risk of aneurysm rupture remains a critical challenge. We hypothesize that vertebral artery fusiform aneurysm (VAFA) morphology may be predictive of rupture risk and can serve as a deciding factor in clinical management. To investigate the VAFA morphology, we use a combination of image analysis and machine learning techniques to study a geometric feature set computed from a depository of 37 (12 ruptured and 25 un-ruptured) aneurysm images. Of the 571 unique features we compute, we distinguish five features for use by our machine learning classification algorithm by an analysis of statistical significance. These machine learning methods achieve state-of-the-art classification performance (81.43 ± 13.08%) for the VAFA morphology, and identify five features (cross-sectional area change of aneurysm, maximum diameter of nearby distal vessel, solidity of aneurysm, maximum curvature of nearby distal vessel, and ratio of curvature between aneurysm and its nearby proximal vessel) as effective predictors of VAFA rupture risk. These results suggest that the geometric features of VAFA morphology may serve as useful non-invasive indicators for the prediction of aneurysm rupture risk in surgical settings.

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Section: Introductionmentioning

confidence: 99%

Vertebral artery fusiform aneurysm geometry in predicting rupture risk

et al. 2018

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Can biomechanical analysis shed some light on aneurysmal pathophysiology? Preliminary study on ex vivo cerebral arterial walls

Brunasso¹,

Alotta

Zingales

et al. 2021

Clinical Biomechanics

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A pilot study on biaxial mechanical, collagen microstructural, and morphological characterizations of a resected human intracranial aneurysm tissue

Laurence

Homburg

Feng

et al. 2021

Sci Rep

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Intracranial aneurysms (ICAs) are focal dilatations that imply a weakening of the brain artery. Incidental rupture of an ICA is increasingly responsible for significant mortality and morbidity in the American’s aging population. Previous studies have quantified the pressure-volume characteristics, uniaxial mechanical properties, and morphological features of human aneurysms. In this pilot study, for the first time, we comprehensively quantified the mechanical, collagen fiber microstructural, and morphological properties of one resected human posterior inferior cerebellar artery aneurysm. The tissue from the dome of a right posterior inferior cerebral aneurysm was first mechanically characterized using biaxial tension and stress relaxation tests. Then, the load-dependent collagen fiber architecture of the aneurysm tissue was quantified using an in-house polarized spatial frequency domain imaging system. Finally, optical coherence tomography and histological procedures were used to quantify the tissue’s microstructural morphology. Mechanically, the tissue was shown to exhibit hysteresis, a nonlinear stress-strain response, and material anisotropy. Moreover, the unloaded collagen fiber architecture of the tissue was predominantly aligned with the testing Y-direction and rotated towards the X-direction under increasing equibiaxial loading. Furthermore, our histological analysis showed a considerable damage to the morphological integrity of the tissue, including lack of elastin, intimal thickening, and calcium deposition. This new unified characterization framework can be extended to better understand the mechanics-microstructure interrelationship of aneurysm tissues at different time points of the formation or growth. Such specimen-specific information is anticipated to provide valuable insight that may improve our current understanding of aneurysm growth and rupture potential.

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On the mechanics of cerebral aneurysms: experimental research and numerical simulation

Cited by 5 publications

References 10 publications

Vertebral artery fusiform aneurysm geometry in predicting rupture risk

Vertebral artery fusiform aneurysm geometry in predicting rupture risk

Can biomechanical analysis shed some light on aneurysmal pathophysiology? Preliminary study on ex vivo cerebral arterial walls

A pilot study on biaxial mechanical, collagen microstructural, and morphological characterizations of a resected human intracranial aneurysm tissue

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