1970
DOI: 10.1113/jphysiol.1970.sp009178
|View full text |Cite
|
Sign up to set email alerts
|

On the mode of action of ACTH on the isolated perfused adrenal gland

Abstract: SUMMARY1. Isolated cat adrenal glands were perfused with Locke solution, and the corticosteroid outputs in response to adrenocorticotrophin (ACTH) were studied.2. Steroid outputs varied with the ACTH concentration, as well as with the duration of exposure to a given ACTH concentration.3. Omission of calcium from the perfusion medium markedly depressed ACTH-evoked steroid release. The steroid output was directly related to the extracellular calcium concentration up to 0 5 mM.4. During a constant exposure to ACT… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
28
0

Year Published

1970
1970
2004
2004

Publication Types

Select...
5
2

Relationship

1
6

Authors

Journals

citations
Cited by 45 publications
(28 citation statements)
references
References 31 publications
0
28
0
Order By: Relevance
“…It was shown that ACTH itself, or stress-induced increased ACTH secretion, exert tropic (short-term) and trophic (long-term) effects on the adrenocortical zona fasciculata (ZF) and zona reticularis (ZR). Tropic effects involve an immediate increase in corticosteroid hormone secretion, which appears about 10·min after the beginning of stress and reaches the maximum 15-30·min later (Jaanus et al, 1970;Normand et al, 1982). The trophic effect of ACTH involves an increase in adrenal mass and in the steroidogenic capacity of adrenocortical cells .…”
mentioning
confidence: 99%
“…It was shown that ACTH itself, or stress-induced increased ACTH secretion, exert tropic (short-term) and trophic (long-term) effects on the adrenocortical zona fasciculata (ZF) and zona reticularis (ZR). Tropic effects involve an immediate increase in corticosteroid hormone secretion, which appears about 10·min after the beginning of stress and reaches the maximum 15-30·min later (Jaanus et al, 1970;Normand et al, 1982). The trophic effect of ACTH involves an increase in adrenal mass and in the steroidogenic capacity of adrenocortical cells .…”
mentioning
confidence: 99%
“…The idea that some cellular calcium pool is critical for ACTH action is in harmony with the finding that corticosteroid secretion was better correlated with the calcium content of cortices rather than with the calcium concentration of Locke solution. ACTH elicits similar rates of steroid secretion when glands are perfused with Locke solution containing 0.5 and 2-0 mm calcium (Jaanus et al 1970); and the calcium content of cortices is very similar after perfusion with 0 5 and 2-0 mm calcium, when a correction is made for the extracellular calcium.…”
Section: Discussionmentioning
confidence: 90%
“…ACTH-induced steroidogenesis in rabbit adrenal glands is not associated with changes in membrane potential (Matthews & Saffran, 1967), which makes it unlikely that the action of ACTH involves marked changes in cell permeability to ions. Under normal conditions, ACTH increases corticosteroid production and the hormone is immediately liberated (Vogt, 1943;Holzbauer & Newport, 1969), although in the absence of calcium the effects of ACTH on steroid synthesis and release can be dissociated (Jaanus et al 1970). The mechanism by which corticosteroid reaches the extracellular space is still a matter of conjecture.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations