On the mode of decrease of leukemic cells during treatment of acute leukemia

Masaoka, Toru; Hasegawa, Yoshihisa; Ueda, T; Takubo, Takayuki; Shibata, Hirotoshi; Nakamura, Hiroyuki; Tatsumi, Noriyuki; Yoshitake, Junsuke; Senda, N.

doi:10.1016/0014-2964(76)90218-8

Cited by 3 publications

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“…Complete and partial remission was diagnosed by the critcria of Kimura (6), i.e. in complete remission there are less than 5% of leukoblasts in the bone marrow with recovery of mature granulocytes and platelets, in seven of the previously untreated cases, thc decrease of leukemic cells in the blood and bone marrow and of neutrophil leukocytes was analysed as previously reported (7). In this study by analysing the curves of cell decrease, we were able to estimate log decrease, the days to maximum rate of decrease, maximum rate of decrease and duration of decrease.…”

Section: Methodsmentioning

confidence: 99%

A phase II study of mitoxantrone in acute leukemia

et al. 1985

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A phase II study of mitoxantrone (Novantrone; dihydroxyanthracenedione) was conducted in 35 patients (22 male: 13 female) with acute leukemia. There were 35 evaluable cases with a mean age of 34 (range 8-61). Twenty-eight patients had acute non-lymphocytic leukemia (ANLL) and seven had acute lymphocytic leukemia (ALL). Mitoxantrone was administered intravenously 2-4 mg/m2 daily for five days and after the nadir a further 2-3 doses were added if necessary. All previously treated cases (22 patients) had been treated with anthracyclines; 13 had no previous treatment. Out of the 13 untreated cases there were six complete remissions (CRs) (46.2%) and five partial remissions (PRs) (38.5%), while out of 22 pretreated cases, four CRs (18.2%) and five PRs (22.7%) were obtained. In seven of the untreated cases the decrease of leukemic cells and neutrophil leukocytes were analysed. Mitoxantrone showed a longer duration of decrease and higher log decrease of leukemic cells in the bone marrow than daunorubicin or cytosine arabinoside. Seventy-three percent of patients showed gastrointestinal disturbances such as nausea or loss of appetite. In 38.1% SGPT elevation and in 8.8% abnormal ECG findings were observed. All side-effects were mild and reversible. From this data mitoxantrone seems a very promising agent in the treatment of acute leukemia and a phase III study is now being carried out.

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Section: Methodsmentioning

confidence: 99%

A phase II study of mitoxantrone in acute leukemia

et al. 1985

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“…Dynemicin A, [1] Terbinafine [2,3] (Lamisil®), callipeltosides [4] or Neocarzinostatin [5] ], nitronates, especially cyclic nitronates, find application in the synthesis of biologically active compounds, [6,7] drug candidates [8][9][10] and natural products. While the structural motif of a conjugated enyne occurs in many pharmaceuticals and natural compounds [e.g.…”

Section: Introductionmentioning

confidence: 99%

“…While the structural motif of a conjugated enyne occurs in many pharmaceuticals and natural compounds [e.g. Dynemicin A, [1] Terbinafine [2,3] (Lamisil®), callipeltosides [4] or Neocarzinostatin [5] ], nitronates, especially cyclic nitronates, find application in the synthesis of biologically active compounds, [6,7] drug candidates [8][9][10] and natural products. [11] Due to the fundamental structural dissimilarities between cyclic nitronates and conjugated enynes, these compounds are generally accessed by disparate strategies.…”

Section: Introductionmentioning

confidence: 99%

Unprecedented Mechanism of an Organocatalytic Route to Conjugated Enynes with a Junction to Cyclic Nitronates

et al. 2018

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Conjugated enynes as well as cyclic nitronates are crucial building blocks for numerous natural products and pharmaceuticals. However, so far, no common and metal‐free synthetic route to both conjugated enynes and cyclic nitronates has been reported. Herein, in situ NMR, labelling studies and theoretical calculations were combined to investigate the mechanism of the unusual triple bond formation towards conjugated enynes. Starting from nitroalkene dimers, first an isoxazolidine‐2,5‐diol derivative is formed as central intermediate. From this, enynes were generated by a combination of oxidation, dehydration, and retro 1,3‐dipolar cycloaddition, whereas for nitronates a base induced intramolecular reorganization is proposed. While the product distribution could be controlled and high yields of nitronate were achieved, only medium to good yields for enynes were obtained due to polymerization losses. Nevertheless, we hope that these mechanistic investigations may provide a basis for further developments of organocatalytic or metal‐free preparations of conjugated enynes and nitronates.

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Cytotoxic and mutagenic effects of neocarzinostatin in wild-type and repair-deficient yeasts

Mousstacchi

Favaudon

1982

Mutation Research Letters

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On the mode of decrease of leukemic cells during treatment of acute leukemia

Cited by 3 publications

References 0 publications

A phase II study of mitoxantrone in acute leukemia

A phase II study of mitoxantrone in acute leukemia

Unprecedented Mechanism of an Organocatalytic Route to Conjugated Enynes with a Junction to Cyclic Nitronates

Cytotoxic and mutagenic effects of neocarzinostatin in wild-type and repair-deficient yeasts

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