On the mode of inheritance of double-muscled conformation in bovines

Rollins, W. C.; Tanaka, Moira; Nott, C. F. G.; Thiessen, R.

doi:10.3733/hilg.v41n14p433

Cited by 37 publications

(13 citation statements)

References 8 publications

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“…In the Piedmontese breed, the condition is caused by a partially dominant to completely dominant gene (Ramondi, 1964). However, the same gene locus is responsible for the double-muscled condition in both British and European breeds of cattle (Rollins et al, 1972). In swine, the halothane gene is a recessive gene with incomplete penetrance (Smith and Bampton, 1977;Reik et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Phenotypic characterization of rambouillet sheep expressing the callipyge gene: I. Inheritance of the condition and production characteristics.

Jackson

Green

Miller

1997

Journal of Animal Science

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The objectives of this study were to determine the model of inheritance of the callipyge gene and to evaluate the growth, ADFI, feed efficiency, reproductive performance, and wool growth of sheep that are heterozygous for the callipyge gene. Ewes (n = 236) with a normal muscle phenotype and genotype were mated to three heterozygous rams that expressed the callipyge gene. Lambs (n = 311) were subjectively classified at weaning (90 to 120d) according to muscle phenotype by a panel of three evaluators working independently. The callipyge muscle phenotype was expressed in 150 lambs, whereas 161 lambs expressed a normal muscle phenotype. The percentage of lambs expressing the callipyge muscle phenotype (48.2%) did not differ (P > .1) from the expected 50%. Growth rate was similar for lambs of both phenotypes regardless of sex. Feed efficiency was superior (P < .05) for both male and female lambs with the callipyge muscle phenotype. Average daily feed intake was lower for male (P < .02) and female (P < .004) lambs with the callipyge muscle phenotype. Grease fleece weight and staple length at 12 mo were superior (P < .03) for ewes with a normal muscle phenotype. These results indicate that the callipyge gene in sheep is dominant when inherited from the paternal parent and lambs expressing the callipyge gene have increased feed efficiency and reduced ADFL.

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Section: Discussionmentioning

confidence: 99%

Phenotypic characterization of rambouillet sheep expressing the callipyge gene: I. Inheritance of the condition and production characteristics.

Jackson

Green

Miller

1997

Journal of Animal Science

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“…Double‐muscled cattle also show a reduced fertility relative to normal cattle, and it has been observed that DM cattle were less capable of carrying to term (Strath et al 1981). It has been suggested that DM embryos have a higher mortality rate (Rollins et al. 1972).…”

Section: Physiological Evaluation Of Double Musclingmentioning

confidence: 99%

Myostatinand its implications on animal breeding: a review

et al. 2005

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Myostatin, or growth and differentiation factor 8 (GDF8), has been identified as the factor causing a phenotype known as double muscling, in which a series of mutations render the gene inactive, and therefore, unable to regulate muscle fibre deposition. This phenotype occurs at a high frequency in some breeds of cattle such as Belgian Blue and Peidmontese. Phylogenetic analysis has shown that there has been positive selection pressure for non-synonymous mutations within the myostatin gene family, around the time of the divergence of cattle, sheep and goats, and these positive selective pressures on non-ancestral myostatin are relatively recent. To date, there have been reports of nine mutations in coding regions of myostatin that cause non-synonymous changes, of which three cause missense mutations, including two in exon 1 and one in exon 2. The remaining six mutations, located in exons 2 and 3, result in premature stop codons, which are the mutations responsible for the double-muscling phenotype. Unfortunately, breed management problems exist for double-muscled cattle, such as birthing difficulties, which can be overcome through genetically controlled breeding programmes, as shown in this review.

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“…However, genes with a large effect (major genes) on quantitative traits have been identified in recent years. Well‐known examples are the dwarf gene in poultry (Mérat & Ricard 1974), the halothane sensitivity gene in pigs (Smith & Bampton 1977), the Booroola gene affecting ovulation rate in sheep (Piper & Bindon 1982) and the double muscling gene in cattle (Rollins et al . 1972).…”

Section: Introductionmentioning

confidence: 99%

Trial for detecting carriers with major genes in a selected layer line

Ochiai

Ishida

Oyama

et al. 2005

Animal Science Journal

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Production traits of a Rhode Island Red layer line were analyzed to detect carrier animals with major genes that influenced a particular trait by applying the major gene index (MGI) approach. This method was used to examine the deviation of predicted breeding values between parents and offspring. Advantages of this method include its simplicity and time‐reducing, cost‐saving benefits compared with any other statistical approach for screening major genes. The layer line had been selected based on the desired gain index for 6 years at the National Livestock Breeding Center, Okazaki station. The line consisted of 125 sires and 2986 dams. Two economic traits as breeding objectives were studied – age at sexual maturity (ASM, days) and egg production efficiency (EP, %). The MGI detected nine sires and 23 dams as carriers with major genes for ASM, and five sires and 26 dams for EP. They were identified as important breeding stock, and pedigree information provided candidates possessing major genes with favorable effect at the founding of the selected layer line. It seems likely that the simple approach of the MGI could be a useful preliminary method for detecting carrier animals with major genes before applying molecular techniques on a sampled population to identify in more detail the existence of major genes and their carriers.

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On the mode of inheritance of double-muscled conformation in bovines

Cited by 37 publications

References 8 publications

Phenotypic characterization of rambouillet sheep expressing the callipyge gene: I. Inheritance of the condition and production characteristics.

Phenotypic characterization of rambouillet sheep expressing the callipyge gene: I. Inheritance of the condition and production characteristics.

Myostatinand its implications on animal breeding: a review

Trial for detecting carriers with major genes in a selected layer line

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