On the molecular mechanism of nonspecific antimicrobial action of protonated diallylammonium polymers on mycobacterial cells

Timofeeva, L. M.; Бондаренко, Г. Н.; Nikitushkin, Vadim D.; Simonova, Yulia; Topchiy, Maxim A.; Eremenko, Ivan; Shleeva, Margarita O.; Mulyukin, A. L.; Kaprelyants, Arseny S.

doi:10.1016/j.eurpolymj.2022.111214

Cited by 4 publications

(4 citation statements)

References 42 publications

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“…However, the other polymer microparticles, PSPMA‐Cl and PSPMA‐NH 2 showed relative increase in the antimicrobial activity compared to PSPMA and this could be attributed to the introduction of chloride and amino surface groups unto PSPMA‐Cl and PSPMA‐NH 2 respectively. Polymethacrylates, polynorbornenes, polycarbonates, polypeptides and polyamides as well other polymer classes are believed to possess variability and adaptability in the properties like morphology, polymer chain chemistry, biodegradability, hydrophobic and cationic surface groups, which can be to achieve desirable antimicrobial activities and low toxicities 56–60 …”

Section: Resultsmentioning

confidence: 99%

“…Polymethacrylates, polynorbornenes, polycarbonates, polypeptides and polyamides as well other polymer classes are believed to possess variability and adaptability in the properties like morphology, polymer chain chemistry, biodegradability, hydrophobic and cationic surface groups, which can be to achieve desirable antimicrobial activities and low toxicities. [56][57][58][59][60] Generally, sessile biofilm bacterial cells can resist the presence of antibiotics and very few antibiotics are capable of disrupting and dispersing biofilms and destroying the exopolyssacharide protective sheath and kill the quiescent cells. 61 Biofilms can be formed on abiotic as well as biotic surfaces and the prevention of biofilm formation usually involves creating a hydrophilic and non-fouling surface.…”

Section: Antimicrobial and Antibiofilm Activitiesmentioning

confidence: 99%

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Synthesis of cross‐linked diazaborine‐based polymeric microparticles with antiquorum sensing, anti‐swarming, antimicrobial, and antibiofilm properties

Tamfu

Koçak

Ceylan

et al. 2023

J of Applied Polymer Sci

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Transmission of infectious diseases and resistance by microorganisms is a global health threat. Antimicrobial polymers are increasingly being developed as biocides with greater applications than traditional antibiotics. In this study, 3‐(potassiumsulfonyl)propyl methacrylate (SPMA) monomer, ethylene glycol dimethacrylate cross‐linker and ammonium persulfate initiator were reacted to yield poly[3‐(potassiumsulfonyl)propyl methacrylate] microgels (PSPMA). Surface modification of PSPMA with thionyl chloride yielded poly[3‐(chlorosulfonyl)propyl methacrylate microparticle] (PSPMA‐Cl) which was reacted with hydrazinehydrate to obtain poly[3‐(hydrazinylsulfonyl)propyl methacrylate] microparticles (PSPMA‐NH2). Finally, 2‐formyl benzeneboronic acid was added to give the final product poly[3‐((1‐hydroxybenzo(d)(1,2,3)diazaborinin‐2(1H)‐yl)sulfonyl)propyl methacrylate] (PSPMA‐DAZ) microparticles. The modified microparticles were characterized using attenuated total reflectance‐Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy and energy‐dispersive x‐ray analyses. The polymeric microparticles showed good antibiofilm activity against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Candida albicans ATCC 10239 and Candida tropicalis ATCC 13803 while low to moderate biofilm inhibitions were observed against Listeria monocytogenes ATCC 7644, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853 and Salmonella typhi ATCC 14028. Surface group modification from PSPMA, PSPMA‐Cl, PSPMA‐NH2 to PSPMA‐DAZ increased violacein inhibition, quorum‐sensing inhibition and antimicrobial activity but reduced swarming. These polymer microparticles can be used to reduce spread of microbial infections and resistance.

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Section: Resultsmentioning

confidence: 99%

Section: Antimicrobial and Antibiofilm Activitiesmentioning

confidence: 99%

Synthesis of cross‐linked diazaborine‐based polymeric microparticles with antiquorum sensing, anti‐swarming, antimicrobial, and antibiofilm properties

Tamfu

Koçak

Ceylan

et al. 2023

J of Applied Polymer Sci

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“…Noncovalent hydrogen bonding between the polymer and membrane leads to destruction of the organism. 53 This targeting of polymers to M.tb. can be of two types: active and passive (Figure 5).…”

Section: Worldwide Statisticsmentioning

confidence: 99%

“…To check the interaction between the cationic polymer and M.tb cell membrane, secondary poly(diallylammonium trifluoroacetate) and phenolic glycolipids (similar to the outer membranes of M.tb and Msm) were considered. Noncovalent hydrogen bonding between the polymer and membrane leads to destruction of the organism . This targeting of polymers to M.tb .…”

Section: Specific Diseasesmentioning

confidence: 99%

Progress in Treatment and Diagnostics of Infectious Disease with Polymers

Patra,

Pareek,

Gupta

et al. 2024

ACS Infect. Dis.

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In this era of advanced technology and innovation, infectious diseases still cause significant morbidity and mortality, which need to be addressed. Despite overwhelming success in the development of vaccines, transmittable diseases such as tuberculosis and AIDS remain unprotected, and the treatment is challenging due to frequent mutations of the pathogens. Formulations of new or existing drugs with polymeric materials have been explored as a promising new approach. Variations in shape, size, surface charge, internal morphology, and functionalization position polymer particles as a revolutionary material in healthcare. Here, an overview is provided of major diseases along with statistics on infection and death rates, focusing on polymer-based treatments and modes of action. Key issues are discussed in this review pertaining to current challenges and future perspectives.

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Molecular Properties of Protonated Diallylammonium Polymers Synthesized via Reversible Addition−Fragmentation Chain-Transfer Polymerization

Yevlampieva,

Vezo,

Slyusarenko

et al. 2023

Polym. Sci. Ser. A

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On the molecular mechanism of nonspecific antimicrobial action of protonated diallylammonium polymers on mycobacterial cells

Cited by 4 publications

References 42 publications

Synthesis of cross‐linked diazaborine‐based polymeric microparticles with antiquorum sensing, anti‐swarming, antimicrobial, and antibiofilm properties

Synthesis of cross‐linked diazaborine‐based polymeric microparticles with antiquorum sensing, anti‐swarming, antimicrobial, and antibiofilm properties

Progress in Treatment and Diagnostics of Infectious Disease with Polymers

Molecular Properties of Protonated Diallylammonium Polymers Synthesized via Reversible Addition−Fragmentation Chain-Transfer Polymerization

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