On the multiscale modeling of heart valve biomechanics in health and disease

Weinberg, Eli J.; Shahmirzadi, Danial; Mofrad, Mohammad R. K.

doi:10.1007/s10237-009-0181-2

Cited by 68 publications

(53 citation statements)

References 148 publications

(162 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found this approach to accelerate the process of mitral valve modelling for patient-specific analysis. There are also several recent review papers on mitral valve research, each with a different focus (Sacks et al 2009;Einstein et al 2010;Weinberg et al 2010).…”

Section: Introductionmentioning

confidence: 98%

Effect of bending rigidity in a dynamic model of a polyurethane prosthetic mitral valve

Luo

Griffith

et al. 2011

Biomech Model Mechanobiol

View full text Add to dashboard Cite

We investigate the behaviour of a dynamic fluid-structure interaction model of a chorded polyurethane mitral valve prosthesis, focusing on the effects on valve dynamics of including descriptions of the bending stiffnesses of the valve leaflets and artificial chordae tendineae. Each of the chordae is attached at one end to the valve annulus and at the other to one of two chordal attachment points. These attachment points correspond to the positions where the chords of the real prosthesis would attach to the left-ventricular wall, although in the present study, these attachment points are kept fixed in space to facilitate comparison between our simulations and earlier results obtained from an experimental test rig. In our simulations, a time-dependent pressure difference derived from experimental measurements drives flow through the model valve during diastole and provides a realistic pressure load during systole. In previous modelling studies of this valve prosthesis, the valve presents an unrealistically large orifice at beginning of diastole and does not close completely at the end of diastole. We show that including a description of the chordal bending stiffness enables the model valve to close properly at the end of the diastolic phase of the cardiac cycle. Valve over-opening is eliminated only by incorporating a description of the bending stiffnesses of the valve leaflets into the model. Thus, bending stiffness plays a significant role in the dynamic behaviour of the polyurethane mitral valve prosthesis.

show abstract

Section: Introductionmentioning

confidence: 98%

Effect of bending rigidity in a dynamic model of a polyurethane prosthetic mitral valve

Luo

Griffith

et al. 2011

Biomech Model Mechanobiol

View full text Add to dashboard Cite

show abstract

“…The constitutive response of biomaterials can be correlated to the physical structure of living tissues and with eventual abnormalities, resulting into diagnosing techniques [42,43]. The links between biomechanics and human diseases have been the subject of considerable scientific research efforts [44][45][46][47]. Recent developments of the study of biological systems has reached a point where it can benefit considerably from contributions from continuum mechanics, which have provided a framework to analyze and predict the behavior of biomechanical mechanisms without specifically modeling the properties at the cellular and molecular levels [48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Sensing linear viscoelastic constitutive parameters with a Timoshenko beam on a multi-layer foundation: Modeling and simulation

Fattahi

Spinello

2015

Sensing and Bio-Sensing Research

View full text Add to dashboard Cite

a b s t r a c tWe present a sensor model comprised of a Timoshenko beam coupled with a linear viscoelastic substrate via a distributed system of compliant elements. The system of governing equations includes the evolution of the kinematic descriptors of the Timoshenko beam and of the interface between the coupling elements and the viscoelastic substrate. This model is used to pose an inverse problem aimed at estimating the constitutive parameters of the substrate from deformation measurements of the beam. The sensing model is demonstrated by comparing its prediction with published experimentally obtained constitutive parameters identifying standard linear viscoelastic material models, showing good agreement between model estimations and experimental results.

show abstract

“…Various works on multi-scale modelling of heart valves exist in literature, where the problem at hand is tackled at organ, tissue, cell and molecular scales [7,8].…”

Section: Introductionmentioning

confidence: 99%

Multi-scale modelling of textile reinforced artificial tubular aortic heart valves

et al. 2016

View full text Add to dashboard Cite

Tissue engineered heart valves equivalent to the native aortic heart valves are in development as an alternative to available prostheses. To achieve sufficient mechanical stiffness for application in tissue engineered valves exposed to the systemic circulation, the tissue is reinforced by a textile scaffold. Mechanical testing of structurally different textiles used as reinforcement in tissue engineered heart valves is expensive and time-consuming. The current study seeks to predict the behaviour of textile reinforced artificial heart valves using a multi-scale modelling approach. The complex textile structure was divided into simplified models at different scales. Virtual experiments were conducted on each of these models and their response was fitted by appropriate isotropic and anisotropic hyperelastic material models. The textile response was then used in a macro heart valve model, which was subjected to dynamic cardiac loading. It was shown that the current modelling approach is in good agreement with the real valve behaviour.

show abstract

On the multiscale modeling of heart valve biomechanics in health and disease

Cited by 68 publications

References 148 publications

Effect of bending rigidity in a dynamic model of a polyurethane prosthetic mitral valve

Effect of bending rigidity in a dynamic model of a polyurethane prosthetic mitral valve

Sensing linear viscoelastic constitutive parameters with a Timoshenko beam on a multi-layer foundation: Modeling and simulation

Multi-scale modelling of textile reinforced artificial tubular aortic heart valves

Contact Info

Product

Resources

About