On the natural chemoprevention of cancer

Saunders, Fiona; Wallace, Heather M.

doi:10.1016/j.plaphy.2010.03.001

Cited by 47 publications

(33 citation statements)

References 68 publications

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“…[3][4][5][6] Actually, several studies have established a direct relationship between the intake of polyphenols and the prevention of oxidative stress-induced diseases, namely neurodegenerative and cardiovascular disorders, and some types of cancer. 7,8 The isoflavone daidzein (DAID), in particular, is the second most abundant component of soybean (following genistein), a growingly consumed food product, which renders this isoflavone a very suitable target of study regarding its potential health beneficial effects.…”

Section: A Introductionmentioning

confidence: 99%

Raman microspectroscopy for probing the impact of a dietary antioxidant on human breast cancer cells

et al. 2016

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Breast cancer is the second most common type of cancer worldwide and the most frequent among women, being the fifth cause of death from neoplastic disease. Since this is an oxidative-stress related neoplasia, it is largely preventable. A dietary isoflavone abundant in soybean -daidzein -was currently investigated as to its chemopreventive and/or chemotherapeutic properties towards the human MDA-MB-231 (metastatic, estrogen-unresponsive) and MCF-7 (estrogen-responsive) breast cancer cell lines. Biological assays for evaluation of antitumour and anti-invasive activities were combined with state-of-theart vibrational microspectroscopy techniques. At 50 and 100 µM concentrations and 48 h incubation time, daidzein was found to induce a marked decrease in cell viability (ca. 50%) for MDA-MB-231 and MCF-7 cells (respectively ca. 50% and 42%) and 40% inhibition of cell migration 48 h. MicroRaman analysis of fixed cells upon exposure to this isoflavone unveiled its metabolic impact on both cell lines. Multivariate data analysis (unsupervised PCA) led to a clear discrimination between control and DAID-exposed cells, with distinctive effects on their biochemical profile, particularly regarding DNA, lipids and protein components, in a cell-dependent way. This is the first reported study on the impact of dietary antioxidants on cancer cells by microRaman techniques. A IntroductionCancer is one of the major causes of morbidity and mortality worldwide, closely following cardiovascular disorders. Breast carcinoma, in particular, is an important public health problem since it is the second most lethal cancer among women worldwide: according to the World Health Organisation (WHO), it affects 28% of the women in Europe 1 , being the second most lethal cancer type in Portugal (16%). 2 Epidemiological evidence has demonstrated a clear difference in breast cancer incidence between eastern and western countries, asian women being the least affected, which can be closely related to dietary habits.Phytochemicals, secondary plant metabolites widespread in fruits, vegetables, cereals and beverages such as tea, coffee and wine, and very abundant in a mediterranean diet, are an abundant source of dietary antioxidants known to significantly decrease the harmful effect of oxidative species, thus being promising chemopreventive agents towards carcinogenesis. [3][4][5][6] Actually, several studies have established a direct relationship between the intake of polyphenols and the prevention of oxidative stress-induced diseases, namely neurodegenerative and cardiovascular disorders, and some types of cancer. 7,8 The isoflavone daidzein (DAID), in particular, is the second most abundant component of soybean (following genistein), a growingly consumed food product, which renders this isoflavone a very suitable target of study regarding its potential health beneficial effects. In addition, it exhibits structural and functional similarities to the endogenous hormone estrogen 9 (Fig. 1). Since some breast cancers are estrogen-dependent (ER + ), DAID may...

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Section: A Introductionmentioning

confidence: 99%

Raman microspectroscopy for probing the impact of a dietary antioxidant on human breast cancer cells

et al. 2016

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“…Proof of concept of chemoprevention has been shown with the non-steroidal antiinflammatory drugs, however there is significantly more interest in plant and naturally available compounds for chemoprevention. In this respect, more and more researchers paid much attention to a number of different naturally occurring chemical compounds for cancer chemoprevention and treatment (Saunders and Wallace, 2010). In the present study, SDE which was previously found to exert antineoplastic effect (Lin et al, 1994;Pan et al, 2001), was clearly demonstrated to kill all three human tumor cell lines, such as CNE, SMMC-7721, BGC-823.…”

Section: Discussionmentioning

confidence: 54%

Reactive oxygen species-mediated mitochondrial dysfunction is involved in apoptosis in human nasopharyngeal carcinoma CNE cells induced by Selaginella doederleinii extract

Liu

et al. 2011

Journal of Ethnopharmacology

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“…The idea that these polyphenols, which approximately has 8,000 varieties, can play a role in preventing cancer has recently created the necessity to illuminate the mechanisms of their action in cancer cells (Han et al 2007;Ramos, 2007;Saunders & Wallace, 2010).…”

Section: Inhibition Of Telomerase and Induction Of Apoptosis By Othermentioning

confidence: 99%

Inhibiting Telomerase Activity and Inducing Apoptosis in Cancer Cells by Several Natural Food Compounds

Coşan¹,

Soyocak²

2012

Reviews on Selected Topics of Telomere Biology

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On the natural chemoprevention of cancer

Cited by 47 publications

References 68 publications

Raman microspectroscopy for probing the impact of a dietary antioxidant on human breast cancer cells

Raman microspectroscopy for probing the impact of a dietary antioxidant on human breast cancer cells

Reactive oxygen species-mediated mitochondrial dysfunction is involved in apoptosis in human nasopharyngeal carcinoma CNE cells induced by Selaginella doederleinii extract

Inhibiting Telomerase Activity and Inducing Apoptosis in Cancer Cells by Several Natural Food Compounds

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