On the nature and rôle of the fatty acids essential in nutrition

Burr, George O.; Burr, Mildred M.

doi:10.1016/0163-7827(81)90004-7

Cited by 135 publications

(164 citation statements)

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“…They are required for various biological processes, not just for producing energy, but cannot be synthesized from other food components, and are considered essential fatty acids (Burr et al, 1930). In the skin of vertebrates, they maintain the epidermal water barrier (Hansen and Jensen, 1985) and are metabolized by skin epidermal enzymes generating potent biologically active oxidative metabolites.…”

Section: Discussionmentioning

confidence: 99%

Chemical Constituents of the Femoral Gland Secretions of Male Tegu Lizards (Tupinambis merianae) (Family Teiidae)

Martı́n

Chamut

Manes

et al. 2011

Zeitschrift Für Naturforschung C

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In spite of the importance of chemical signals (pheromones) in the reproductive behaviour of lizards, the chemical compounds secreted by their femoral glands, which may be used as sexual signals, are only known for a few lizard species. Based on mass spectra, obtained by GC-MS, we found 49 lipophilic compounds in femoral gland secretions of male tegu lizards (Tupinambis merianae) (fam. Teiidae), including a very high proportion of carboxylic acids and their esters ranging between n-C 8 and n-C 20 (mainly octadecanoic and 9,12-octadecadienoic acids), with much less proportions of steroids, tocopherol, aldehydes, and squalene. We discuss the potential function of these compounds in secretions, and compare the compounds found here with those documented for other lizard species.

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Section: Discussionmentioning

confidence: 99%

Chemical Constituents of the Femoral Gland Secretions of Male Tegu Lizards (Tupinambis merianae) (Family Teiidae)

Martı́n

Chamut

Manes

et al. 2011

Zeitschrift Für Naturforschung C

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“…It may be of interest to note that linoleic acid deficiency retards animal growth and that butter efficiently restores the weight lost in rats given fat-free diets (Burr and Burr, 1930;Aaes-Jorgensen, 1961). Although linoleic acid has been shown to be one active component, phytanic acid may represent another of their postulated "vitamine F" growth-promoting substances (Evans and Burr, 1928).…”

Section: Phytol Metabolites As Transcriptional Signalsmentioning

confidence: 99%

Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR.

Kitareewan

Burka

Tomer

et al. 1996

MBoC

179

135

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RXR is a nuclear receptor that plays a central role in cell signaling by pairing with a host of other receptors. Previously, 9-cis-retinoic acid (9cRA) was defined as a potent RXR activator. Here we describe a unique RXR effector identified from organic extracts of bovine serum by following RXR-dependent transcriptional activity. Structural analyses of material in active fractions pointed to the saturated diterpenoid phytanic acid, which induced RXR-dependent transcription at concentrations between 4 and 64 ,uM. Although 200 times more potent than phytanic acid, 9cRA was undetectable in equivalent amounts of extract and cannot be present at a concentration that could account for the activity. Phytenic acid, another phytol metabolite, was synthesized and stimulated RXR with a potency and efficacy similar to phytanic acid. These metabolites specifically displaced[3H]-9cRA from RXR with Ki values of 4 ,uM, indicating that their transcriptional effects are mediated by direct receptor interactions. Phytol metabolites are compelling candidates for physiological effectors, because their RXR binding affinities and activation potencies match their micromolar circulating concentrations. Given their exclusive dietary origin, these chlorophyll metabolites may represent essential nutrients that coordinate cellular metabolism through RXR-dependent signaling pathways.

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“…Therefore, there is currently great interest in the regulation of HUFA biosynthesis in fish to determine the effectiveness with which vegetable oils can be utilized to replace FO in the diets of commercially important cultured fish species . PUFAs,; LA) and linolenate LNA), cannot be synthesized de novo by animals, including fish and, therefore, are termed essential fatty acids (EFA) (Burr and Burr, 1929;Holman, 1986). The EFA requirement of fish differs between species.…”

Section: Introductionmentioning

confidence: 99%

Effect of partial substitution of dietary fish oil by vegetable oils on desaturation and β-oxidation of [1-14C]18:3n−3 (LNA) and [1-14C]20:5n−3 (EPA) in hepatocytes and enterocytes of European sea bass (Dicentrarchus labrax L.)

et al. 2005

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On the nature and rôle of the fatty acids essential in nutrition

Cited by 135 publications

References 0 publications

Chemical Constituents of the Femoral Gland Secretions of Male Tegu Lizards (Tupinambis merianae) (Family Teiidae)

Chemical Constituents of the Femoral Gland Secretions of Male Tegu Lizards (Tupinambis merianae) (Family Teiidae)

Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR.

Effect of partial substitution of dietary fish oil by vegetable oils on desaturation and β-oxidation of [1-14C]18:3n−3 (LNA) and [1-14C]20:5n−3 (EPA) in hepatocytes and enterocytes of European sea bass (Dicentrarchus labrax L.)

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